Luteolin inhibits endothelin-1 secretion in cultured endothelial cells

We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibitio...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-08, Vol.69 (8), p.1613-1615
Main Authors: Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)), Yamanaka, A, Ichiba, T, Toyokawa, T, Kamada, Y, Tamamura, T, Ichimura, T, Maruyama, S
Format: Article
Language:English
Subjects:
Animals
ARTERIES
Base Sequence
Biological and medical sciences
CELL CULTURE
DNA Primers
Dose-Response Relationship, Drug
endothelin
Endothelin-1 - genetics
Endothelin-1 - secretion
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - secretion
flavonoid
FLAVONOIDS
Fundamental and applied biological sciences. Psychology
GENE EXPRESSION
Gene Expression Regulation - drug effects
GLYCOSIDES
INHIBITION
luteolin
Luteolin - pharmacology
SECRETION
SWINE
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Summary:We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.1613