Loading…
Luteolin inhibits endothelin-1 secretion in cultured endothelial cells
We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibitio...
Saved in:
| Published in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-08, Vol.69 (8), p.1613-1615 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3 |
| container_end_page | 1615 |
| container_issue | 8 |
| container_start_page | 1613 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 69 |
| creator | Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)) Yamanaka, A Ichiba, T Toyokawa, T Kamada, Y Tamamura, T Ichimura, T Maruyama, S |
| description | We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak. |
| doi_str_mv | 10.1271/bbb.69.1613 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_17213407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3123299591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3</originalsourceid><addsrcrecordid>eNpt0c9rFDEUB_Agil2rJ8_KgNhLmW1eMvMmOUppq7KgB3sOmfywKdlJTWYo_e-bZVcWxFwCL5_3eHxDyHuga2ADXIzjuEa5BgT-gqyAd0OLshtekhWVgK3oejghb0q5p7QWenhNTqoFZLJfkevNMrsUw9SE6S6MYS6Nm2ya71yttdAUZ7KbQ9q9N2aJ85KdPRIdG-NiLG_JK69jce8O9ym5vb76dfm13fy4-Xb5ZdMa7PjcDmC04YidRUDkAiXlDpgfBQrjOVhOtdWegtfOMMuktIJ1vZBCDwbNyE_J2X7uQ05_FldmtQ1lt4GeXFqKQtFTUU-Fn_6B92nJU91NQddJAcAFrep8r0xOpWTn1UMOW52fFFC1C1fVcBVKtQu36o-Hmcu4dfZoD2lW8PkAdDE6-qwnE8rRDaz-Dh2qw70Lk095qx9TjlbN-imm_LeJ_3-DD_tGr5PSv3N1338ySpFS4Az5M8mnnCc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449811380</pqid></control><display><type>article</type><title>Luteolin inhibits endothelin-1 secretion in cultured endothelial cells</title><source>Oxford Journals Online</source><source>EZB Electronic Journals Library</source><creator>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)) ; Yamanaka, A ; Ichiba, T ; Toyokawa, T ; Kamada, Y ; Tamamura, T ; Ichimura, T ; Maruyama, S</creator><creatorcontrib>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)) ; Yamanaka, A ; Ichiba, T ; Toyokawa, T ; Kamada, Y ; Tamamura, T ; Ichimura, T ; Maruyama, S</creatorcontrib><description>We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.69.1613</identifier><identifier>PMID: 16116295</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; ARTERIES ; Base Sequence ; Biological and medical sciences ; CELL CULTURE ; DNA Primers ; Dose-Response Relationship, Drug ; endothelin ; Endothelin-1 - genetics ; Endothelin-1 - secretion ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - secretion ; flavonoid ; FLAVONOIDS ; Fundamental and applied biological sciences. Psychology ; GENE EXPRESSION ; Gene Expression Regulation - drug effects ; GLYCOSIDES ; INHIBITION ; luteolin ; Luteolin - pharmacology ; SECRETION ; SWINE</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2005-08, Vol.69 (8), p.1613-1615</ispartof><rights>2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3</citedby><cites>FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17213407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16116295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan))</creatorcontrib><creatorcontrib>Yamanaka, A</creatorcontrib><creatorcontrib>Ichiba, T</creatorcontrib><creatorcontrib>Toyokawa, T</creatorcontrib><creatorcontrib>Kamada, Y</creatorcontrib><creatorcontrib>Tamamura, T</creatorcontrib><creatorcontrib>Ichimura, T</creatorcontrib><creatorcontrib>Maruyama, S</creatorcontrib><title>Luteolin inhibits endothelin-1 secretion in cultured endothelial cells</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.</description><subject>Animals</subject><subject>ARTERIES</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>CELL CULTURE</subject><subject>DNA Primers</subject><subject>Dose-Response Relationship, Drug</subject><subject>endothelin</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - secretion</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - secretion</subject><subject>flavonoid</subject><subject>FLAVONOIDS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE EXPRESSION</subject><subject>Gene Expression Regulation - drug effects</subject><subject>GLYCOSIDES</subject><subject>INHIBITION</subject><subject>luteolin</subject><subject>Luteolin - pharmacology</subject><subject>SECRETION</subject><subject>SWINE</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpt0c9rFDEUB_Agil2rJ8_KgNhLmW1eMvMmOUppq7KgB3sOmfywKdlJTWYo_e-bZVcWxFwCL5_3eHxDyHuga2ADXIzjuEa5BgT-gqyAd0OLshtekhWVgK3oejghb0q5p7QWenhNTqoFZLJfkevNMrsUw9SE6S6MYS6Nm2ya71yttdAUZ7KbQ9q9N2aJ85KdPRIdG-NiLG_JK69jce8O9ym5vb76dfm13fy4-Xb5ZdMa7PjcDmC04YidRUDkAiXlDpgfBQrjOVhOtdWegtfOMMuktIJ1vZBCDwbNyE_J2X7uQ05_FldmtQ1lt4GeXFqKQtFTUU-Fn_6B92nJU91NQddJAcAFrep8r0xOpWTn1UMOW52fFFC1C1fVcBVKtQu36o-Hmcu4dfZoD2lW8PkAdDE6-qwnE8rRDaz-Dh2qw70Lk095qx9TjlbN-imm_LeJ_3-DD_tGr5PSv3N1338ySpFS4Az5M8mnnCc</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan))</creator><creator>Yamanaka, A</creator><creator>Ichiba, T</creator><creator>Toyokawa, T</creator><creator>Kamada, Y</creator><creator>Tamamura, T</creator><creator>Ichimura, T</creator><creator>Maruyama, S</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Luteolin inhibits endothelin-1 secretion in cultured endothelial cells</title><author>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan)) ; Yamanaka, A ; Ichiba, T ; Toyokawa, T ; Kamada, Y ; Tamamura, T ; Ichimura, T ; Maruyama, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>ARTERIES</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>CELL CULTURE</topic><topic>DNA Primers</topic><topic>Dose-Response Relationship, Drug</topic><topic>endothelin</topic><topic>Endothelin-1 - genetics</topic><topic>Endothelin-1 - secretion</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - secretion</topic><topic>flavonoid</topic><topic>FLAVONOIDS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE EXPRESSION</topic><topic>Gene Expression Regulation - drug effects</topic><topic>GLYCOSIDES</topic><topic>INHIBITION</topic><topic>luteolin</topic><topic>Luteolin - pharmacology</topic><topic>SECRETION</topic><topic>SWINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan))</creatorcontrib><creatorcontrib>Yamanaka, A</creatorcontrib><creatorcontrib>Ichiba, T</creatorcontrib><creatorcontrib>Toyokawa, T</creatorcontrib><creatorcontrib>Kamada, Y</creatorcontrib><creatorcontrib>Tamamura, T</creatorcontrib><creatorcontrib>Ichimura, T</creatorcontrib><creatorcontrib>Maruyama, S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozakai, T. (National Inst. of Advanced Industrial Science and Technology Tsukuba, Ibaraki (Japan))</au><au>Yamanaka, A</au><au>Ichiba, T</au><au>Toyokawa, T</au><au>Kamada, Y</au><au>Tamamura, T</au><au>Ichimura, T</au><au>Maruyama, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Luteolin inhibits endothelin-1 secretion in cultured endothelial cells</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>69</volume><issue>8</issue><spage>1613</spage><epage>1615</epage><pages>1613-1615</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 micro m. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>16116295</pmid><doi>10.1271/bbb.69.1613</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2005-08, Vol.69 (8), p.1613-1615 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_17213407 |
| source | Oxford Journals Online; EZB Electronic Journals Library |
| subjects | Animals ARTERIES Base Sequence Biological and medical sciences CELL CULTURE DNA Primers Dose-Response Relationship, Drug endothelin Endothelin-1 - genetics Endothelin-1 - secretion Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - secretion flavonoid FLAVONOIDS Fundamental and applied biological sciences. Psychology GENE EXPRESSION Gene Expression Regulation - drug effects GLYCOSIDES INHIBITION luteolin Luteolin - pharmacology SECRETION SWINE |
| title | Luteolin inhibits endothelin-1 secretion in cultured endothelial cells |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T13%3A53%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Luteolin%20inhibits%20endothelin-1%20secretion%20in%20cultured%20endothelial%20cells&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=Kozakai,%20T.%20(National%20Inst.%20of%20Advanced%20Industrial%20Science%20and%20Technology%20Tsukuba,%20Ibaraki%20(Japan))&rft.date=2005-08-01&rft.volume=69&rft.issue=8&rft.spage=1613&rft.epage=1615&rft.pages=1613-1615&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/10.1271/bbb.69.1613&rft_dat=%3Cproquest_pasca%3E3123299591%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c643t-71cac3664d6166386903e12fb868cf31d30adaf01faec2d299d8245898a7c6cb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1449811380&rft_id=info:pmid/16116295&rfr_iscdi=true |