Cognitive Performance by Humans During a Smoked Cocaine Binge-Abstinence Cycle

Five cocaine-dependent individuals completed a 22-day inpatient study of sleep and cognition. Following 3 days of drug-free baseline, participants underwent 3 days of twice-daily smoked cocaine base self-administration (6 50-mg doses, 14 minutes apart), followed by 15 days of abstinence. Each mornin...

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Bibliographic Details
Published in:The American journal of drug and alcohol abuse 2005-01, Vol.31 (4), p.571-591
Main Authors: Pace-Schott, Edward F., Stickgold, Robert, Muzur, Amir, Wigren, Pia E., Ward, Amie S., Hart, Carl L., Walker, Matthew, Edgar, Chris, Hobson, J. Allan
Format: Article
Language:English
Subjects:
abstinence
Addictive behaviors
Adult
Adult and adolescent clinical studies
attention
binge
Biological and medical sciences
Chronic Disease
Circadian Rhythm
Cocaine
Cocaine-Related Disorders - epidemiology
cognition
Cognition & reasoning
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Diagnosis, Computer-Assisted
Drug abuse
Drug addiction
Female
Fundamental and applied biological sciences. Psychology
Human subjects
Humans
Male
Medical sciences
memory
Neuropsychological Tests
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time
repeated assessments
Smoking
Substance Withdrawal Syndrome - epidemiology
Substance Withdrawal Syndrome - psychology
Toxicology
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Summary:Five cocaine-dependent individuals completed a 22-day inpatient study of sleep and cognition. Following 3 days of drug-free baseline, participants underwent 3 days of twice-daily smoked cocaine base self-administration (6 50-mg doses, 14 minutes apart), followed by 15 days of abstinence. Each morning and afternoon, the CDR repeatable, multiple-version, computerized cognitive battery (whose stability following practice has been documented) was administered. During abstinence, performance deteriorated on vigilance tasks (especially reaction time) as well as on immediate and delayed verbal recognition tasks but not on working memory tasks. Declines were most evident in the afternoon. Data suggest that abstinence can unmask cognitive deficits induced by chronic cocaine use and circadian factors may mediate their severity.
ISSN:0095-2990
1097-9891
DOI:10.1081/ADA-200068120