The Influence of Magnesium Stearate on the Hiestand Tableting Indices and Other Related Mechanical Properties of Maltodextrins

Magnesium stearate is widely used as a lubricant in pharmaceutical dosage forms. A film of magnesium stearate, or other lubricant, around individual granules is generally considered to cause the softening of tablets. Maltodextrins were chosen as model excipients since maltodextrins possessing a seri...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2005-01, Vol.10 (4), p.461-466
Main Authors: Wurster, Dale Eric, Likitlersuang, Sukhon, Chen, Yisheng
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug Stability
Excipients - chemistry
General pharmacology
Hardness Tests
Hiestand Tableting Indices
magnesium stearate
maltodextrins
Medical sciences
Molecular Weight
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polysaccharides - chemistry
Stearic Acids - chemistry
Tablets
Technology, Pharmaceutical - methods
Tensile Strength
Viscosity
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Summary:Magnesium stearate is widely used as a lubricant in pharmaceutical dosage forms. A film of magnesium stearate, or other lubricant, around individual granules is generally considered to cause the softening of tablets. Maltodextrins were chosen as model excipients since maltodextrins possessing a series of molecular weights showed systematically changing consolidation mechanisms. As maltodextrin molecular weight increases, the plasticity of the material increases. The Hiestand Tableting Indices and other related mechanical properties were used to study the effect of magnesium stearate addition on the mechanical properties and consolidation mechanisms of single component maltodextrins. Magnesium stearate was shown to lower the tensile strengths of maltodextrin compacts. Additionally, magnesium stearate addition lowered both the Hiestand Bonding Index and the Hiestand Brittle Fracture Index. The lower values of the Hiestand Brittle Fracture Index indicate that magnesium stearate promotes greater plastic behavior in maltodextrin compacts.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450500299693