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Dengue virus infection: a major cause of acute hepatic failure in Thai children
Background: Acute hepatic failure (AHF) can be caused by a variety of viruses, drugs, toxins and metabolic disorders. Aims: A prospective study was conducted to determine the aetiology and outcome of AHF in Thai children aged 1-15 years. Methods: All serum samples were tested for anti-HAV IgM, HBsAg...
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| Published in: | Annals of tropical paediatrics 2006-03, Vol.26 (1), p.17-23 |
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| container_end_page | 23 |
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| container_title | Annals of tropical paediatrics |
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| creator | Poovorawan, Yong Hutagalung, Yanee Chongsrisawat, Voranush Boudville, Irving Bock, Hans L. |
| description | Background: Acute hepatic failure (AHF) can be caused by a variety of viruses, drugs, toxins and metabolic disorders.
Aims: A prospective study was conducted to determine the aetiology and outcome of AHF in Thai children aged 1-15 years.
Methods: All serum samples were tested for anti-HAV IgM, HBsAg, anti-HBc IgM, anti-HCV, anti-HEV IgM and anti-dengue IgG and IgM. Further individual investigations were done according to the clinical impression.
Results: Forty subjects were enrolled from 14 centres during February 2000 to December 2001. Five cases were excluded owing to a lack of evidence of encephalopathy. The causes of AHF were dengue infection in 12 (34.3%), Wilson disease in 2 (5.7%), T-cell lymphoma in 2 (5.7%), ischaemic hepatitis in two (5.7%), haemophagocytic syndrome in one (2.8%), CMV in 2 (5.7%), Reye syndrome in one (2.8%) and unknown in 13 (37.1%) patients. The fatality rate was 68.6%. Eight of 24 (33.3%) deaths were caused by dengue infection.
Conclusions: Improvements in sanitation and socio-economic status as well as the implementation of hepatitis B vaccine in the Extended Programme on Immunization (EPI) are likely to be the reasons for the observed absence of AHF caused by hepatitis A and B. The study showed that dengue infection, on the other hand, was a major cause of AHF in Thailand. |
| doi_str_mv | 10.1179/146532806X90565 |
| format | article |
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Aims: A prospective study was conducted to determine the aetiology and outcome of AHF in Thai children aged 1-15 years.
Methods: All serum samples were tested for anti-HAV IgM, HBsAg, anti-HBc IgM, anti-HCV, anti-HEV IgM and anti-dengue IgG and IgM. Further individual investigations were done according to the clinical impression.
Results: Forty subjects were enrolled from 14 centres during February 2000 to December 2001. Five cases were excluded owing to a lack of evidence of encephalopathy. The causes of AHF were dengue infection in 12 (34.3%), Wilson disease in 2 (5.7%), T-cell lymphoma in 2 (5.7%), ischaemic hepatitis in two (5.7%), haemophagocytic syndrome in one (2.8%), CMV in 2 (5.7%), Reye syndrome in one (2.8%) and unknown in 13 (37.1%) patients. The fatality rate was 68.6%. Eight of 24 (33.3%) deaths were caused by dengue infection.
Conclusions: Improvements in sanitation and socio-economic status as well as the implementation of hepatitis B vaccine in the Extended Programme on Immunization (EPI) are likely to be the reasons for the observed absence of AHF caused by hepatitis A and B. The study showed that dengue infection, on the other hand, was a major cause of AHF in Thailand.</description><identifier>ISSN: 0272-4936</identifier><identifier>ISSN: 2046-9047</identifier><identifier>EISSN: 1465-3281</identifier><identifier>EISSN: 2046-9055</identifier><identifier>DOI: 10.1179/146532806X90565</identifier><identifier>PMID: 16494700</identifier><identifier>CODEN: ATPAD9</identifier><language>eng</language><publisher>Leeds: Taylor & Francis</publisher><subject>Acute Disease ; Adolescent ; Arboviroses ; Biological and medical sciences ; Biomarkers - blood ; Child ; Child, Preschool ; Dengue - complications ; Dengue - epidemiology ; Dengue - mortality ; Dengue fevers ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis - virology ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; Liver Failure, Acute - etiology ; Liver Failure, Acute - mortality ; Liver Failure, Acute - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Other diseases. Semiology ; Prognosis ; Prospective Studies ; Thailand - epidemiology ; Tropical viral diseases ; Viral diseases</subject><ispartof>Annals of tropical paediatrics, 2006-03, Vol.26 (1), p.17-23</ispartof><rights>2006 Maney 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Taylor & Francis Ltd. Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-7012d707c356851e6716417bd7e6f40624e9d1f970264fa668c728fa9d98c6bc3</citedby><cites>FETCH-LOGICAL-c469t-7012d707c356851e6716417bd7e6f40624e9d1f970264fa668c728fa9d98c6bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17538386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16494700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poovorawan, Yong</creatorcontrib><creatorcontrib>Hutagalung, Yanee</creatorcontrib><creatorcontrib>Chongsrisawat, Voranush</creatorcontrib><creatorcontrib>Boudville, Irving</creatorcontrib><creatorcontrib>Bock, Hans L.</creatorcontrib><title>Dengue virus infection: a major cause of acute hepatic failure in Thai children</title><title>Annals of tropical paediatrics</title><addtitle>Ann Trop Paediatr</addtitle><description>Background: Acute hepatic failure (AHF) can be caused by a variety of viruses, drugs, toxins and metabolic disorders.
Aims: A prospective study was conducted to determine the aetiology and outcome of AHF in Thai children aged 1-15 years.
Methods: All serum samples were tested for anti-HAV IgM, HBsAg, anti-HBc IgM, anti-HCV, anti-HEV IgM and anti-dengue IgG and IgM. Further individual investigations were done according to the clinical impression.
Results: Forty subjects were enrolled from 14 centres during February 2000 to December 2001. Five cases were excluded owing to a lack of evidence of encephalopathy. The causes of AHF were dengue infection in 12 (34.3%), Wilson disease in 2 (5.7%), T-cell lymphoma in 2 (5.7%), ischaemic hepatitis in two (5.7%), haemophagocytic syndrome in one (2.8%), CMV in 2 (5.7%), Reye syndrome in one (2.8%) and unknown in 13 (37.1%) patients. The fatality rate was 68.6%. Eight of 24 (33.3%) deaths were caused by dengue infection.
Conclusions: Improvements in sanitation and socio-economic status as well as the implementation of hepatitis B vaccine in the Extended Programme on Immunization (EPI) are likely to be the reasons for the observed absence of AHF caused by hepatitis A and B. The study showed that dengue infection, on the other hand, was a major cause of AHF in Thailand.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dengue - complications</subject><subject>Dengue - epidemiology</subject><subject>Dengue - mortality</subject><subject>Dengue fevers</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Liver Failure, Acute - etiology</subject><subject>Liver Failure, Acute - mortality</subject><subject>Liver Failure, Acute - virology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Thailand - epidemiology</subject><subject>Tropical viral diseases</subject><subject>Viral diseases</subject><issn>0272-4936</issn><issn>2046-9047</issn><issn>1465-3281</issn><issn>2046-9055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLHDEYhoNU6tb27K0Ewd5Gk0zyJfEm2lpB8KLQ25DNJN0sM5M1mbT475tlVwShpw8-nvfl4UXohJJzSqW-oBxEyxSBX5oIEAdosf009UU_oAVhkjVct3CEPuW8JoRQJdlHdESBay4JWaCHGzf9Lg7_CalkHCbv7BzidIkNHs06JmxNyQ5Hj40ts8MrtzFzsNibMJTkagI_rkzAdhWGPrnpMzr0Zsjuy_4eo6cf3x-vfzb3D7d311f3jeWg50YSynpJpG0FKEEdyKpE5bKXDjwnwLjTPfVaEgbcGwBlJVPe6F4rC0vbHqNvu95Nis_F5bkbQ7ZuGMzkYskdSFBcMKjg6TtwHUuaqltHteAKgIgKXewgm2LOyfluk8Jo0ktHSbcduns3dE183deW5ej6N36_bAXO9oDJ1gw-mcmG_MZJ0apWbf0ud1zdPqbR_I1p6LvZvAwxvYba_1n8A7mTlaA</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Poovorawan, Yong</creator><creator>Hutagalung, Yanee</creator><creator>Chongsrisawat, Voranush</creator><creator>Boudville, Irving</creator><creator>Bock, Hans L.</creator><general>Taylor & Francis</general><general>Maney</general><general>Taylor & Francis Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Dengue virus infection: a major cause of acute hepatic failure in Thai children</title><author>Poovorawan, Yong ; Hutagalung, Yanee ; Chongsrisawat, Voranush ; Boudville, Irving ; Bock, Hans L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-7012d707c356851e6716417bd7e6f40624e9d1f970264fa668c728fa9d98c6bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dengue - complications</topic><topic>Dengue - epidemiology</topic><topic>Dengue - mortality</topic><topic>Dengue fevers</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Liver Failure, Acute - etiology</topic><topic>Liver Failure, Acute - mortality</topic><topic>Liver Failure, Acute - virology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Thailand - epidemiology</topic><topic>Tropical viral diseases</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poovorawan, Yong</creatorcontrib><creatorcontrib>Hutagalung, Yanee</creatorcontrib><creatorcontrib>Chongsrisawat, Voranush</creatorcontrib><creatorcontrib>Boudville, Irving</creatorcontrib><creatorcontrib>Bock, Hans L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of tropical paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poovorawan, Yong</au><au>Hutagalung, Yanee</au><au>Chongsrisawat, Voranush</au><au>Boudville, Irving</au><au>Bock, Hans L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dengue virus infection: a major cause of acute hepatic failure in Thai children</atitle><jtitle>Annals of tropical paediatrics</jtitle><addtitle>Ann Trop Paediatr</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>26</volume><issue>1</issue><spage>17</spage><epage>23</epage><pages>17-23</pages><issn>0272-4936</issn><issn>2046-9047</issn><eissn>1465-3281</eissn><eissn>2046-9055</eissn><coden>ATPAD9</coden><abstract>Background: Acute hepatic failure (AHF) can be caused by a variety of viruses, drugs, toxins and metabolic disorders.
Aims: A prospective study was conducted to determine the aetiology and outcome of AHF in Thai children aged 1-15 years.
Methods: All serum samples were tested for anti-HAV IgM, HBsAg, anti-HBc IgM, anti-HCV, anti-HEV IgM and anti-dengue IgG and IgM. Further individual investigations were done according to the clinical impression.
Results: Forty subjects were enrolled from 14 centres during February 2000 to December 2001. Five cases were excluded owing to a lack of evidence of encephalopathy. The causes of AHF were dengue infection in 12 (34.3%), Wilson disease in 2 (5.7%), T-cell lymphoma in 2 (5.7%), ischaemic hepatitis in two (5.7%), haemophagocytic syndrome in one (2.8%), CMV in 2 (5.7%), Reye syndrome in one (2.8%) and unknown in 13 (37.1%) patients. The fatality rate was 68.6%. Eight of 24 (33.3%) deaths were caused by dengue infection.
Conclusions: Improvements in sanitation and socio-economic status as well as the implementation of hepatitis B vaccine in the Extended Programme on Immunization (EPI) are likely to be the reasons for the observed absence of AHF caused by hepatitis A and B. The study showed that dengue infection, on the other hand, was a major cause of AHF in Thailand.</abstract><cop>Leeds</cop><pub>Taylor & Francis</pub><pmid>16494700</pmid><doi>10.1179/146532806X90565</doi><tpages>7</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Acute Disease Adolescent Arboviroses Biological and medical sciences Biomarkers - blood Child Child, Preschool Dengue - complications Dengue - epidemiology Dengue - mortality Dengue fevers Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis - virology Human viral diseases Humans Infant Infectious diseases Liver Failure, Acute - etiology Liver Failure, Acute - mortality Liver Failure, Acute - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Prognosis Prospective Studies Thailand - epidemiology Tropical viral diseases Viral diseases |
| title | Dengue virus infection: a major cause of acute hepatic failure in Thai children |
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