Clinically active Crohn's disease in the presence of a low C-reactive protein

Objective. Clinical interest in C-reactive protein (CRP) - a component of the innate immune system - has focused mainly on its worth as an indicator of disease activity. There has been a resurgence of interest in CRP in the Crohn's disease (CD) literature because several trials of new treatment...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2006-03, Vol.41 (3), p.306-311
Main Authors: Florin, Timothy H. J., Paterson, Ewan W. J., Fowler, Elizabeth V., Radford-Smith, Graham L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biomarkers - blood
BMI
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Child
Crohn
Crohn Disease - blood
CRP
DNA - genetics
fat wrapping
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
Humans
IBD
inflammatory indicator
Intracellular Signaling Peptides and Proteins - genetics
Male
Medical sciences
Middle Aged
NOD2
Nod2 Signaling Adaptor Protein
Other diseases. Semiology
phenotype
Prognosis
Prospective Studies
Severity of Illness Index
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Vienna classification
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Summary:Objective. Clinical interest in C-reactive protein (CRP) - a component of the innate immune system - has focused mainly on its worth as an indicator of disease activity. There has been a resurgence of interest in CRP in the Crohn's disease (CD) literature because several trials of new treatments for active CD have been characterized by both a large proportion of patients with low CRP ( 200. The low CRP group was compared with patients in the raised CRP group for a range of clinical variables as well as the major NOD2 variants. Results. There were data sets for 223 CD patients, with a mean disease duration of 12 years. Of these, 22 patients fulfilled the criteria for low CRP. The low CRP group (group 1) showed significant differences for disease site (p
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520500217118