Osteopontin Participates in Th1-Mediated Host Resistance against Nonlethal Malaria Parasite Plasmodium chabaudi chabaudi Infection in Mice

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon...

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Bibliographic Details
Published in:Infection and Immunity 2006-04, Vol.74 (4), p.2423-2427
Main Authors: Maeno, Yoshimasa, Nakazawa, Shusuke, Yamamoto, Naoki, Shinzato, Masanori, Nagashima, Shigeo, Tanaka, Kumiko, Sasaki, Jun, Rittling, Susan R, Denhardt, David T, Uede, Toshimitsu, Taniguchi, Koki
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Human protozoal diseases
Immunity, Innate - genetics
Infectious diseases
Interferon-gamma - blood
Interleukin-12 - blood
Kinetics
Malaria
Malaria - blood
Malaria - genetics
Malaria - immunology
Malaria - mortality
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Osteopontin
Parasitic diseases
Plasmodium chabaudi - immunology
Plasmodium chabaudi chabaudi
Protozoal diseases
RNA, Messenger - biosynthesis
Sialoglycoproteins - biosynthesis
Sialoglycoproteins - deficiency
Sialoglycoproteins - genetics
Sialoglycoproteins - physiology
Th1 Cells - immunology
Th1 Cells - parasitology
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Summary:Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.74.4.2423-2427.2006