Antimelanogenic activity of 3,4-dihydroxyacetophenone: Inhibition of tyrosinase and MITF

3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006, Vol.70 (2), p.532-534
Main Authors: Kim, Y.J.(Pusan Women's Coll., Busan (Korea R.)), No, J.K, Lee, J.S, Kim, M.S, Chung, H.Y
Format: Article
Language:English
Subjects:
3,4-dihydroxyacetophenone
Acetophenones - pharmacology
Animals
antimelanogenic activity
Biological and medical sciences
Cell Line, Tumor
CETONAS
CETONE
Enzyme Inhibitors - pharmacology
ESPECTROMETRIA
FACTEUR DE TRANSCRIPTION
FACTORES DE TRANSCRIPCION
Fundamental and applied biological sciences. Psychology
INHIBICION
INHIBITION
KETONES
melanin
MELANINAS
MELANINE
MELANINS
Melanins - biosynthesis
Mice
microphthalmia transcription factor
Microphthalmia-Associated Transcription Factor - antagonists & inhibitors
Microphthalmia-Associated Transcription Factor - metabolism
Monophenol Monooxygenase - antagonists & inhibitors
Monophenol Monooxygenase - metabolism
OXIDOREDUCTASES
OXIDORREDUCTASAS
OXYDOREDUCTASE
SPECTROMETRIE
SPECTROMETRY
TRANSCRIPTION FACTORS
tyrosinase
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Summary:3,4-Dihydroxyacetophenone (3,4-DHAP) was evaluated for antimelanogenic activity. The tyrosinase inhibitory action by 3,4-DHAP using mushroom tyrosinase revealed a strong inhibitory effect. To further explore this matter, inhibition of tyrosinase and melanin content was measured in B16 melanoma cells (B16 cells). Further, tyrosinase and microphthalmia transcription factor (MITF) protein levels were determined by the Western blot method. Additionally, tyrosinase and MITF protein levels were reduced by 3,4DHAP. Our data indicate that the antimelanogenic activity of 3,4DHAP was probably due to its inhibition of tyrosinase activity and the suppression of tyrosinase and MITF protein levels.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70.532