The Endolymphatic Sac, a Potential Endocrine Gland?

A previous investigation indicated that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium re-absorption in the kidneys, which has tentatively been named ?saccin?. In this study, the ultrastructure of the endolymphatic sac and in particular the chief cells is describe...

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Bibliographic Details
Published in:Acta oto-laryngologica 1999-03, Vol.119 (2), p.194-199
Main Author: Klaus Qvortrup, Jørgen Rostgaard, Niels-Henrik Holstein-Rathlou, Poul Bretlau
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Endocrine Glands - physiology
Endolymphatic Sac - cytology
Endolymphatic Sac - physiology
Endolymphatic Sac - ultrastructure
Ent. Stomatology
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Microscopy, Electron
Microscopy, Electron, Scanning
Natriuretic Agents - metabolism
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Rats
Rats, Wistar
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Summary:A previous investigation indicated that the chief cells of the endolymphatic sac produce an endogenous inhibitor of sodium re-absorption in the kidneys, which has tentatively been named ?saccin?. In this study, the ultrastructure of the endolymphatic sac and in particular the chief cells is described, demonstrating that this organ fulfils the morphological criteria of a potential endocrine gland. Accordingly, the chief cells are shown to exhibit all the organelles and characteristics of cells that simultaneously synthesize, secrete, absorb and digest proteins.
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489950181657