Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride

We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml)...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2006-05, Vol.70 (5), p.1242-1245
Main Authors: KOBAYASHI-HATTORI, Kazuo, WATANABE, Takahiro, KIMURA, Kimiko, SUGITA-KONISHI, Yoshiko
Format: Article
Language:English
Subjects:
Animals
ATP Binding Cassette Transporter, Subfamily B - genetics
ATP-Binding Cassette Sub-Family B Member 4
Biological and medical sciences
Down-Regulation
Female
Fundamental and applied biological sciences. Psychology
Gene Expression
Kidney - metabolism
lactation
Lactation - metabolism
Maternal Exposure
mdr1b
Mice
Mice, Inbred ICR
offspring
placenta
Placenta - metabolism
Pregnancy
RNA, Messenger - analysis
RNA, Messenger - metabolism
Trialkyltin Compounds - metabolism
Trialkyltin Compounds - toxicity
tributyltin chloride
Water Pollutants - metabolism
Water Pollutants - toxicity
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Summary:We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.70.1242