Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement

An analogue of acetildenafil was detected in an extract of pre-mixed bulk powder. To our knowledge, the powder was destined to be encapsulated and sold as a dietary supplement. The structure was identified by NMR, HR-ESI-MS, ESI-MSn and FTIR analyses. Owing to the inclusion of a hydroxyl group in ac...

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Bibliographic Details
Published in:Food additives and contaminants 2006-09, Vol.23 (9), p.870-875
Main Authors: Hou, P, Zou, P, Low, M.Y, Chan, E, Koh, H.L
Format: Article
Language:English
Subjects:
adulterated products
adulteration
Biological and medical sciences
chemical composition
chemical structure
Chromatography, High Pressure Liquid - methods
dietary supplements
Dietary Supplements - analysis
electrospray ionization (ESI)
enzyme inhibitors
erectile dysfunction
Erectile Dysfunction - therapy
Feeding. Feeding behavior
Food Analysis - methods
Food Contamination - analysis
Food industries
Fundamental and applied biological sciences. Psychology
General aspects
herbal medicines
Humans
hydroxyacetildenafil
Hygiene and safety
Male
male fertility
microencapsulation
NMR
nuclear magnetic resonance spectroscopy
Phosphodiesterase Inhibitors - chemistry
Phosphodiesterase Inhibitors - isolation & purification
Piperazines - chemistry
Piperazines - isolation & purification
powdered foods
product authenticity
Purines - chemistry
Purines - isolation & purification
Sildenafil Citrate
Spectrometry, Mass, Electrospray Ionization - methods
Sulfones - chemistry
Sulfones - isolation & purification
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:An analogue of acetildenafil was detected in an extract of pre-mixed bulk powder. To our knowledge, the powder was destined to be encapsulated and sold as a dietary supplement. The structure was identified by NMR, HR-ESI-MS, ESI-MSn and FTIR analyses. Owing to the inclusion of a hydroxyl group in acetildenafil, the detected compound was called 'hydroxyacetildenafil'. With increasing use of dietary supplements marketed for penile erectile dysfunction, the detection of analogues of sexual performance enhancers is important and timely.
ISSN:0265-203X
1464-5122
DOI:10.1080/02652030600803856