Investigations into the C-deuteriation of silyl enol ethers derived from aryl alkyl ketones

Results are reported on the regioselective C‐deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D2) gas as the deuterium source and palladium‐on‐barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product ty...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2006-08, Vol.49 (9), p.757-771
Main Authors: Buksha, Svitlana, Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka
Format: Article
Language:English
Subjects:
alkyl aryl ketones
Chemistry
Condensed benzenic and aromatic compounds
deuteriation
Exact sciences and technology
hydrogenation
Organic chemistry
palladium
Preparations and properties
reduction
silyl enol ethers and silyl ethers
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Summary:Results are reported on the regioselective C‐deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D2) gas as the deuterium source and palladium‐on‐barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product types available from simple deuteriation of substituted enol precursors. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.1088