EFFECT OF HYPOTHERMIA ON BLOOD-BRAIN BARRIER PERMEABILITY FOLLOWING TRAUMATIC BRAIN INJURY IN CHRONICALLY ETHANOL-TREATED RATS

• Published in: International journal of neuroscience 2006-11, Vol.116 (11), p.1249-1261
• Main Authors: ARICAN, N., KAYA, M., YORULMAZ, C., KALAYCI, R., INCE, H., KUCUK, M., FINCANCI, S. K., ELMAS, I.
• Format: Article
• Language: English
• Subjects: Accidental Falls - statistics & numerical data; Adult and adolescent clinical studies; Alcohol-Induced Disorders, Nervous System - complications; Alcohol-Induced Disorders, Nervous System - physiopathology; Alcoholism - complications; Alcoholism - physiopathology; Animals; Behavioral psychophysiology; Biological and medical sciences; Blood Pressure - physiology; blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - physiopathology; Body Weight - physiology; Brain - blood supply; Brain - pathology; Brain - physiopathology; Brain Injuries - complications; Brain Injuries - physiopathology; Central Nervous System Depressants - adverse effects; Chronic Disease; cold exposure; Disease Models, Animal; ethanol; Ethanol - adverse effects; Evans Blue; Fundamental and applied biological sciences. Psychology; Hypothermia - complications; Hypothermia - physiopathology; Hypothermia, Induced; Injuries of the nervous system and the skull. Diseases due to physical agents; Male; Medical sciences; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Rats; Rats, Wistar; Risk Factors; Traumas. Diseases due to physical agents; traumatic brain injury
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.1080/00207450600550303

The objective of this study was to investigate the effect of hypothermia on the blood-brain barrier (BBB) disruption caused by traumatic brain injury (TBI) in chronically ethanol-treated rats. BBB permeability was measured using Evans blue (EB) dye. Arterial blood pressure levels of animals in hypothermic groups decreased significantly. The EB dye extravasation into the brain significantly increased in hypothermia and at 6 and 24 h after TBI. In ethanol-treated rats that were subjected to TBI, hypothermia led to a significant decrease in EB dye content in the brain at 24 h but not at 6 h after TBI when compared with TBI alone.