Studies on Biopolymers for Ophthalmic Drug Delivery

A series of polyvinyl alcohol (PVA)-hydroxy propyl methyl cellulose (HPMC) based films and gelrite (gellan gum) based in situ gels were formulated with ciprofloxacin hydrochloride as the drug. Drug diffusion studies were carried out for both the film and in situ gel formulations. The prepared PVA/HP...

Full description

Saved in:
Bibliographic Details
Published in:Journal of macromolecular science. Part A, Pure and applied chemistry Pure and applied chemistry, 2007-02, Vol.44 (2), p.229-234
Main Authors: Ramaiah, Sidda, Kumar, T. M. Pramod, Ravi, Valluru
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
ciprofloxacin
Exact sciences and technology
gellan gum
gelrite
General pharmacology
hydroxy propyl methyl cellulose
Medical sciences
Natural polymers
Ophthalmic delivery
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
polyvinyl alcohol
Starch and polysaccharides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of polyvinyl alcohol (PVA)-hydroxy propyl methyl cellulose (HPMC) based films and gelrite (gellan gum) based in situ gels were formulated with ciprofloxacin hydrochloride as the drug. Drug diffusion studies were carried out for both the film and in situ gel formulations. The prepared PVA/HPMC blends have been characterized for tensile strength behavior and percent elongation at break. Fourier transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were carried out to study the compatibility of the drug and polymers used. Drug diffusion results indicate that the film and gel formulations containing ciprofloxacin were compatible and showed a prolonged drug release pattern. The gelrite formulation was non-irritant and had a good gelling property compared to PVA/HPMC blends.
ISSN:1060-1325
1520-5738
DOI:10.1080/10601320601031416