INHIBITION OF PULMONARY METASTASIS OF MELANOMA B16FO CELLS IN C57BL/6 MICE BY A NUTRIENT MIXTURE CONSISTING OF ASCORBIC ACID, LYSINE, PROLINE, ARGININE, AND GREEN TEA EXTRACT

The authors investigated the effect of a nutrient mixture (NM) on lung metastasis by B16F0 melanoma cells in C57BL/6 female mice. Mice were divided into equal groups (1 to 6) and injected via tail vein with B16F0 cells (groups 1 to 4), B16FO cells pretreated with NM (group 5), or saline (group 6). G...

Full description

Saved in:
Bibliographic Details
Published in:Experimental lung research 2006-01, Vol.32 (10), p.517-530
Main Authors: Roomi, M. Waheed, Roomi, Nusrath, Ivanov, Vadim, Kalinovsky, Tatiana, Niedzwiecki, Aleksandra, Rath, Matthias
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - pharmacology
antitumor effect
Arginine - pharmacology
Ascorbic Acid - pharmacology
Biological and medical sciences
Camellia sinensis
Dietary Supplements
Drug Screening Assays, Antitumor
Female
in vivo
Lung - drug effects
Lung - pathology
Lung Neoplasms - drug therapy
Lung Neoplasms - secondary
Lysine - pharmacology
malignant melanoma
Medical sciences
Melanoma - drug therapy
Melanoma - pathology
metastasis
Mice
Mice, Inbred C57BL
Neoplasm Metastasis - drug therapy
Neoplasm Metastasis - pathology
nutrient mixture
Plant Extracts - pharmacology
Pneumology
Proline - pharmacology
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The authors investigated the effect of a nutrient mixture (NM) on lung metastasis by B16F0 melanoma cells in C57BL/6 female mice. Mice were divided into equal groups (1 to 6) and injected via tail vein with B16F0 cells (groups 1 to 4), B16FO cells pretreated with NM (group 5), or saline (group 6). Groups 1, 3, 4, 5, and 6 were fed the control diet and group 2 the 0.5% NM supplemented diet. Groups 3 and 4 received NM intraperitoneally (IP) and intravenously (IV), respectively. Two weeks later, pulmonary metastatic colonies were counted. Pulmonary colonization was reduced by 63% in mice supplemented with NM diet, by 86% in mice receiving NM by IP and IV injections, and completely inhibited in mice injected with melanoma cells pretreated with NM. These results show that NM is effective in inhibiting the metastasis of B16FO melanoma cells.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140601098552