Nobilisitine a and B, two masanane-type alkaloids from Clivia nobilis

Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano [3,4- g]indole ring system and therefore belong to the same subgroup of Amaryllid...

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Published in:Phytochemistry (Oxford) 1999-08, Vol.51 (8), p.1151-1155
Main Authors: Evidente, Antonio, Abou-Donia, Amina H, Darwish, Fikria A, Amer, Masouda E, Kassem, Fahima F, Hammoda, Hal A.m, Motta, Andrea
Format: Article
Language:English
Subjects:
alkaloids
Biological and medical sciences
chemical constituents of plants
Chemical constitution
chemical structure
clivia nobilis
Fundamental and applied biological sciences. Psychology
lactones
nuclear magnetic resonance spectroscopy
Plant physiology and development
spectral analysis
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Summary:Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano [3,4- g]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 β-hydroxy-3a,11c- epi-masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5a-hydroxy-5a- epi-masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)00714-6