Loading…
Determination of isocyanate biomarkers in construction site workers
Abstract 4,4′-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate in the manufacture of polyurethanes, dyes, pigments and adhesives. High concentrations of isocyanates are a potent respiratory irritant. Therefore, it is important to develop methods to monitor exposure to such compo...
Saved in:
| Published in: | Biomarkers 2007-01, Vol.12 (5), p.468-483 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3 |
| container_end_page | 483 |
| container_issue | 5 |
| container_start_page | 468 |
| container_title | Biomarkers |
| container_volume | 12 |
| creator | Sabbioni, Gabriele Wesp, Hansjörg Lewalter, Jürgen Rumler, Richard |
| description | Abstract
4,4′-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate in the manufacture of polyurethanes, dyes, pigments and adhesives. High concentrations of isocyanates are a potent respiratory irritant. Therefore, it is important to develop methods to monitor exposure to such compounds. We monitored biological samples from 40 non-exposed and 45 exposed construction site workers. 4,4′-Methylenedianiline (MDA) and N-acetyl-4,4′-MDA (AcMDA) were determined from untreated urine (U-MDA, U-AcMDA) and MDA was analysed from acid-treated urine (U-MDA-tot). Haemoglobin (Hb) adducts of MDA (Hb-MDA) were determined in all workers. The levels of biomarkers decreased in the following order: U-MDA-tot>U-AcMDA>U-MDA>Hb-MDA. The same order was found for the percentage of samples, which were found positive in exposed workers: 100%, 91%, 91%, 27%. The urine levels U-MDA-tot correlate with U-MDA, U-AcMDA and Hb-MDA with r=0.79, 0.86 and 0.39, respectively (Spearman rank order, p |
| doi_str_mv | 10.1080/13547500701395636 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_19017764</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20491863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoVqsP4EZmo7vRZHKZCbqReoWCGwV3IUkTmjozqckM0rc3vUgRoavkcL7vcM4PwBmCVwhW8BphSkoKYQkR5pRhtgeOEGYspxUk-8s_JXkCPgbgOMYZTFjBq0MwQGVSSsKOwOjedCY0rpWd823mbeai1wuZapMp5xsZPk2ImWsz7dvYhV6vwOhS_9uvmifgwMo6mtPNOwTvjw9vo-d8_Pr0Mrob55ow2uUMKV6WVEKjsJ0wwnmhKMHSWAsryoqCUs65spanGkNEKkNVoQhEhmvEJR6Cy_XcefBfvYmdaFzUpq5la3wfRQEJRxXDCURrUAcfYzBWzINLlywEgmKZnPiXXHLON8N71ZjJ1thElYCLDSCjlrUNstUubjmesJKRxN2uOddaHxqZQqonopOL2odfCe_a4-aPPjWy7qZaBiNmvg9tCnjHFT_YSJr1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20491863</pqid></control><display><type>article</type><title>Determination of isocyanate biomarkers in construction site workers</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Sabbioni, Gabriele ; Wesp, Hansjörg ; Lewalter, Jürgen ; Rumler, Richard</creator><creatorcontrib>Sabbioni, Gabriele ; Wesp, Hansjörg ; Lewalter, Jürgen ; Rumler, Richard</creatorcontrib><description><![CDATA[Abstract
4,4′-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate in the manufacture of polyurethanes, dyes, pigments and adhesives. High concentrations of isocyanates are a potent respiratory irritant. Therefore, it is important to develop methods to monitor exposure to such compounds. We monitored biological samples from 40 non-exposed and 45 exposed construction site workers. 4,4′-Methylenedianiline (MDA) and N-acetyl-4,4′-MDA (AcMDA) were determined from untreated urine (U-MDA, U-AcMDA) and MDA was analysed from acid-treated urine (U-MDA-tot). Haemoglobin (Hb) adducts of MDA (Hb-MDA) were determined in all workers. The levels of biomarkers decreased in the following order: U-MDA-tot>U-AcMDA>U-MDA>Hb-MDA. The same order was found for the percentage of samples, which were found positive in exposed workers: 100%, 91%, 91%, 27%. The urine levels U-MDA-tot correlate with U-MDA, U-AcMDA and Hb-MDA with r=0.79, 0.86 and 0.39, respectively (Spearman rank order, p<0.01). U-AcMDA correlates with U-MDA and Hb-MDA with r=0.77 and 0.47, respectively (p<0.01). U-MDA correlates with Hb-MDA (r=0.38, p<0.05). The levels in the controls were significantly lower than in the exposed workers for all compounds (Mann-Whitney test, p<0.01). The median isocyanate-specific IgE-level was higher in the exposed workers, but the difference was statistically not significant. The change of the biomarker levels was compared in a group of workers (n=20), which were analysed prior to isocyanate exposure and after the exposure for ∼4-7 months. All urine MDA metabolites and the Hb-adduct levels increased significantly (Wilcoxon sign test, p<0.01). Total IgE increased significantly after the exposure with isocyanate activity (p<0.01). With the present work it could be shown that outdoor workers are exposed to a similar extent as workers from a MDI factory.]]></description><identifier>ISSN: 1354-750X</identifier><identifier>EISSN: 1366-5804</identifier><identifier>DOI: 10.1080/13547500701395636</identifier><identifier>PMID: 17701746</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>4,4′-methylenediphenyl diisocyanate ; Acetanilides - urine ; Adult ; Aniline Compounds - urine ; Biological and medical sciences ; Biomarkers - urine ; Biomonitoring ; Chemical and industrial products toxicology. Toxic occupational diseases ; Construction Materials - adverse effects ; Environmental Monitoring - methods ; Female ; haemoglobin adducts ; Hemoglobins - analysis ; Hemoglobins - metabolism ; Humans ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; isocyanates ; Isocyanates - immunology ; Isocyanates - metabolism ; Isocyanates - urine ; Male ; Medical sciences ; Middle Aged ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Occupational Exposure - prevention & control ; Seasons ; Surveys and Questionnaires ; Toluene 2,4-Diisocyanate - immunology ; Toxicology ; urine metabolites ; Various organic compounds</subject><ispartof>Biomarkers, 2007-01, Vol.12 (5), p.468-483</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3</citedby><cites>FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19017764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17701746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabbioni, Gabriele</creatorcontrib><creatorcontrib>Wesp, Hansjörg</creatorcontrib><creatorcontrib>Lewalter, Jürgen</creatorcontrib><creatorcontrib>Rumler, Richard</creatorcontrib><title>Determination of isocyanate biomarkers in construction site workers</title><title>Biomarkers</title><addtitle>Biomarkers</addtitle><description><![CDATA[Abstract
4,4′-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate in the manufacture of polyurethanes, dyes, pigments and adhesives. High concentrations of isocyanates are a potent respiratory irritant. Therefore, it is important to develop methods to monitor exposure to such compounds. We monitored biological samples from 40 non-exposed and 45 exposed construction site workers. 4,4′-Methylenedianiline (MDA) and N-acetyl-4,4′-MDA (AcMDA) were determined from untreated urine (U-MDA, U-AcMDA) and MDA was analysed from acid-treated urine (U-MDA-tot). Haemoglobin (Hb) adducts of MDA (Hb-MDA) were determined in all workers. The levels of biomarkers decreased in the following order: U-MDA-tot>U-AcMDA>U-MDA>Hb-MDA. The same order was found for the percentage of samples, which were found positive in exposed workers: 100%, 91%, 91%, 27%. The urine levels U-MDA-tot correlate with U-MDA, U-AcMDA and Hb-MDA with r=0.79, 0.86 and 0.39, respectively (Spearman rank order, p<0.01). U-AcMDA correlates with U-MDA and Hb-MDA with r=0.77 and 0.47, respectively (p<0.01). U-MDA correlates with Hb-MDA (r=0.38, p<0.05). The levels in the controls were significantly lower than in the exposed workers for all compounds (Mann-Whitney test, p<0.01). The median isocyanate-specific IgE-level was higher in the exposed workers, but the difference was statistically not significant. The change of the biomarker levels was compared in a group of workers (n=20), which were analysed prior to isocyanate exposure and after the exposure for ∼4-7 months. All urine MDA metabolites and the Hb-adduct levels increased significantly (Wilcoxon sign test, p<0.01). Total IgE increased significantly after the exposure with isocyanate activity (p<0.01). With the present work it could be shown that outdoor workers are exposed to a similar extent as workers from a MDI factory.]]></description><subject>4,4′-methylenediphenyl diisocyanate</subject><subject>Acetanilides - urine</subject><subject>Adult</subject><subject>Aniline Compounds - urine</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>Biomonitoring</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Construction Materials - adverse effects</subject><subject>Environmental Monitoring - methods</subject><subject>Female</subject><subject>haemoglobin adducts</subject><subject>Hemoglobins - analysis</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>isocyanates</subject><subject>Isocyanates - immunology</subject><subject>Isocyanates - metabolism</subject><subject>Isocyanates - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational Exposure - prevention & control</subject><subject>Seasons</subject><subject>Surveys and Questionnaires</subject><subject>Toluene 2,4-Diisocyanate - immunology</subject><subject>Toxicology</subject><subject>urine metabolites</subject><subject>Various organic compounds</subject><issn>1354-750X</issn><issn>1366-5804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMoVqsP4EZmo7vRZHKZCbqReoWCGwV3IUkTmjozqckM0rc3vUgRoavkcL7vcM4PwBmCVwhW8BphSkoKYQkR5pRhtgeOEGYspxUk-8s_JXkCPgbgOMYZTFjBq0MwQGVSSsKOwOjedCY0rpWd823mbeai1wuZapMp5xsZPk2ImWsz7dvYhV6vwOhS_9uvmifgwMo6mtPNOwTvjw9vo-d8_Pr0Mrob55ow2uUMKV6WVEKjsJ0wwnmhKMHSWAsryoqCUs65spanGkNEKkNVoQhEhmvEJR6Cy_XcefBfvYmdaFzUpq5la3wfRQEJRxXDCURrUAcfYzBWzINLlywEgmKZnPiXXHLON8N71ZjJ1thElYCLDSCjlrUNstUubjmesJKRxN2uOddaHxqZQqonopOL2odfCe_a4-aPPjWy7qZaBiNmvg9tCnjHFT_YSJr1</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Sabbioni, Gabriele</creator><creator>Wesp, Hansjörg</creator><creator>Lewalter, Jürgen</creator><creator>Rumler, Richard</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20070101</creationdate><title>Determination of isocyanate biomarkers in construction site workers</title><author>Sabbioni, Gabriele ; Wesp, Hansjörg ; Lewalter, Jürgen ; Rumler, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>4,4′-methylenediphenyl diisocyanate</topic><topic>Acetanilides - urine</topic><topic>Adult</topic><topic>Aniline Compounds - urine</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>Biomonitoring</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Construction Materials - adverse effects</topic><topic>Environmental Monitoring - methods</topic><topic>Female</topic><topic>haemoglobin adducts</topic><topic>Hemoglobins - analysis</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>isocyanates</topic><topic>Isocyanates - immunology</topic><topic>Isocyanates - metabolism</topic><topic>Isocyanates - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational Exposure - prevention & control</topic><topic>Seasons</topic><topic>Surveys and Questionnaires</topic><topic>Toluene 2,4-Diisocyanate - immunology</topic><topic>Toxicology</topic><topic>urine metabolites</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabbioni, Gabriele</creatorcontrib><creatorcontrib>Wesp, Hansjörg</creatorcontrib><creatorcontrib>Lewalter, Jürgen</creatorcontrib><creatorcontrib>Rumler, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabbioni, Gabriele</au><au>Wesp, Hansjörg</au><au>Lewalter, Jürgen</au><au>Rumler, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of isocyanate biomarkers in construction site workers</atitle><jtitle>Biomarkers</jtitle><addtitle>Biomarkers</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>12</volume><issue>5</issue><spage>468</spage><epage>483</epage><pages>468-483</pages><issn>1354-750X</issn><eissn>1366-5804</eissn><abstract><![CDATA[Abstract
4,4′-Methylenediphenyl diisocyanate (MDI) is the most important isocyanate in the manufacture of polyurethanes, dyes, pigments and adhesives. High concentrations of isocyanates are a potent respiratory irritant. Therefore, it is important to develop methods to monitor exposure to such compounds. We monitored biological samples from 40 non-exposed and 45 exposed construction site workers. 4,4′-Methylenedianiline (MDA) and N-acetyl-4,4′-MDA (AcMDA) were determined from untreated urine (U-MDA, U-AcMDA) and MDA was analysed from acid-treated urine (U-MDA-tot). Haemoglobin (Hb) adducts of MDA (Hb-MDA) were determined in all workers. The levels of biomarkers decreased in the following order: U-MDA-tot>U-AcMDA>U-MDA>Hb-MDA. The same order was found for the percentage of samples, which were found positive in exposed workers: 100%, 91%, 91%, 27%. The urine levels U-MDA-tot correlate with U-MDA, U-AcMDA and Hb-MDA with r=0.79, 0.86 and 0.39, respectively (Spearman rank order, p<0.01). U-AcMDA correlates with U-MDA and Hb-MDA with r=0.77 and 0.47, respectively (p<0.01). U-MDA correlates with Hb-MDA (r=0.38, p<0.05). The levels in the controls were significantly lower than in the exposed workers for all compounds (Mann-Whitney test, p<0.01). The median isocyanate-specific IgE-level was higher in the exposed workers, but the difference was statistically not significant. The change of the biomarker levels was compared in a group of workers (n=20), which were analysed prior to isocyanate exposure and after the exposure for ∼4-7 months. All urine MDA metabolites and the Hb-adduct levels increased significantly (Wilcoxon sign test, p<0.01). Total IgE increased significantly after the exposure with isocyanate activity (p<0.01). With the present work it could be shown that outdoor workers are exposed to a similar extent as workers from a MDI factory.]]></abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>17701746</pmid><doi>10.1080/13547500701395636</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1354-750X |
| ispartof | Biomarkers, 2007-01, Vol.12 (5), p.468-483 |
| issn | 1354-750X 1366-5804 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19017764 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | 4,4′-methylenediphenyl diisocyanate Acetanilides - urine Adult Aniline Compounds - urine Biological and medical sciences Biomarkers - urine Biomonitoring Chemical and industrial products toxicology. Toxic occupational diseases Construction Materials - adverse effects Environmental Monitoring - methods Female haemoglobin adducts Hemoglobins - analysis Hemoglobins - metabolism Humans Immunoglobulin E - blood Immunoglobulin E - immunology isocyanates Isocyanates - immunology Isocyanates - metabolism Isocyanates - urine Male Medical sciences Middle Aged Occupational Exposure - adverse effects Occupational Exposure - analysis Occupational Exposure - prevention & control Seasons Surveys and Questionnaires Toluene 2,4-Diisocyanate - immunology Toxicology urine metabolites Various organic compounds |
| title | Determination of isocyanate biomarkers in construction site workers |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T09%3A21%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determination%20of%20isocyanate%20biomarkers%20in%20construction%20site%20workers&rft.jtitle=Biomarkers&rft.au=Sabbioni,%20Gabriele&rft.date=2007-01-01&rft.volume=12&rft.issue=5&rft.spage=468&rft.epage=483&rft.pages=468-483&rft.issn=1354-750X&rft.eissn=1366-5804&rft_id=info:doi/10.1080/13547500701395636&rft_dat=%3Cproquest_pasca%3E20491863%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c465t-61b9775a0eb3fd64992b543aeff08562255999bff9f0830148e5b2b401e9c19a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20491863&rft_id=info:pmid/17701746&rfr_iscdi=true |