Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior

Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal releas...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2007-01, Vol.12 (5), p.473-479
Main Authors: Heinicke, Grant, Schwartz, Joseph B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Availability
Buffers
Carbohydrates - chemistry
Cellulose - chemistry
Delayed-Action Preparations
Diltiazem - administration & dosage
Diltiazem - chemistry
Diltiazem - pharmacokinetics
drug release
Excipients - chemistry
General pharmacology
Hydrochloric Acid - chemistry
Medical sciences
Microscopy, Electron, Scanning
osmotic pressure
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymethacrylate
Polymethacrylic Acids - chemistry
Quaternary Ammonium Compounds - chemistry
Vasodilator Agents - administration & dosage
Vasodilator Agents - chemistry
Vasodilator Agents - pharmacokinetics
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Summary:Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. Expansion of coated sugar spheres was measured.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450701557089