Drug Release from Ammonio-Methacrylate-Coated Diltiazem Particles: Influence of the Reservoir on Membrane Behavior

• Published in: Pharmaceutical development and technology 2007-01, Vol.12 (5), p.473-479
• Main Authors: Heinicke, Grant, Schwartz, Joseph B.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biological Availability; Buffers; Carbohydrates - chemistry; Cellulose - chemistry; Delayed-Action Preparations; Diltiazem - administration & dosage; Diltiazem - chemistry; Diltiazem - pharmacokinetics; drug release; Excipients - chemistry; General pharmacology; Hydrochloric Acid - chemistry; Medical sciences; Microscopy, Electron, Scanning; osmotic pressure; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; polymethacrylate; Polymethacrylic Acids - chemistry; Quaternary Ammonium Compounds - chemistry; Vasodilator Agents - administration & dosage; Vasodilator Agents - chemistry; Vasodilator Agents - pharmacokinetics
• ISSN: 1083-7450; 1097-9867
• DOI: 10.1080/10837450701557089

Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release. Lag time depended on the applied polymer amount, the media used, and the sugar content, where an increase in sugar content caused greater expansion before drug release. Lag times were related to expansion. Expansion of coated sugar spheres was measured.