Tetracycline Sensitive Membrane Electrodes Based on Poly (Vinyl Chloride) Matrices and their use in Drug Analysis

• Published in: Analytical letters 1999-01, Vol.32 (11), p.2177-2190
• Main Authors: El-Ansary, A.L., Issa, Y.M., Tag-Eldin, A.S.
• Format: Article
• Language: English
• Subjects: Analysis; Biological and medical sciences; Coated wire; General pharmacology; Ion-selective electrodes; Medical sciences; Pharmacology. Drug treatments; Phosphotungstate; Potentiometry; Tetracycline hydrochloride
• ISSN: 0003-2719; 1532-236X
• DOI: 10.1080/00032719908542962

Tetracycline hydrochloride-selective electrodes of both the coated wire and the conventional polymer membrane types have been prepared. They are based on incorporating the tetracycline-phosphotungstate ion-associate in plasticized poly(vinyl chloride) film. A Nernstian response is shown by these electrodes within certain concentration ranges depending on the type of electrode. The effect of pH of the test solution and time of soaking on the electrodes' performance are studied. The electrodes are highly selective for tetracycline with respect to several inorganic cations, sugars and some amino-acids of significant importance in biological fluids and pharmaceutical preparations. The standard cell potentials, E°, were determined at different temperatures and used to calculate the isothermal temperature coefficient of the cell. Tetracycline is determined successfully in pure solutions and in pharmaceutical preparation using the standard additions method and potentiometric titration.