Differential regulation of enteric and systemic salmonellosis by slyA

Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to...

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Bibliographic Details
Published in:Infection and Immunity 1999-09, Vol.67 (9), p.4950-4954
Main Authors: Watson, P.R, Paulin, S.M, Bland, A.P, Libby, S.J, Jones, P.W, Wallis, T.S
Format: Article
Language:English
Subjects:
Animals
Bacterial diseases
Bacterial Proteins
Bacterial Toxins - genetics
Bacteriology
Biological and medical sciences
Cattle
Experimental bacterial diseases and models
experimental infections
Fundamental and applied biological sciences. Psychology
Genetics
Hemolysin Proteins - genetics
ileum
Infectious diseases
Intestinal Mucosa - pathology
intestines
Medical sciences
Microbiology
Molecular and Cellular Pathogenesis
oral administration
regulator genes
Salmonella Infections, Animal - pathology
Salmonella typhimurium
Salmonella typhimurium - genetics
Salmonella typhimurium - isolation & purification
Salmonella typhimurium - pathogenicity
Transcription Factors
Virulence
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Summary:Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not enteric, salmonellosis.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.67.9.4950-4954.1999