Antiproliferative activity of flavonoids on several cancer cell lines

Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines....

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1999-05, Vol.63 (5), p.896-899
Main Authors: Kawaii, S. (National Inst. of Fruit Tree Science, Tsukuba, Ibaraki (Japan)), Tomono, Y, Katase, E, Ogawa, K, Yano, M
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
antiproliferative activity
Biological and medical sciences
cancer cell lines
Cell Division - drug effects
Cell Line
CITRUS
Drug Screening Assays, Antitumor
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Flavonoids - chemistry
Flavonoids - pharmacology
General pharmacology
human foreskin keratinocytes
human umbilical vein endothelial cells
Humans
Medical sciences
NEOPLASMAS
NEOPLASME
NEOPLASMS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PHYSIOLOGICAL REGULATION
REGULACION FISIOLOGICA
REGULATION PHYSIOLOGIQUE
Structure-Activity Relationship
Tumor Cells, Cultured
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Summary:Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important fort the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.63.896