Maternally Transmitted Antigen of Mice: A Model Transplantation Antigen

Molecular identification proved Mta, the maternally transmitted antigen of mice, to be a model minor histocompatibility (H) antigen. It consists of a peptide, MTF, that is presented on the cell surface by an H-2 class-I molecule, HMT. MTF is derived from ND1, a mitochondrially encoded protein, and t...

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Bibliographic Details
Published in:Annual review of immunology 1991-01, Vol.9 (1), p.351-372
Main Authors: Lindahl, K F, Hermel, E, Loveland, B E, Wang, C R
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens
Biological and medical sciences
Chromosome Mapping
Cloning, Molecular
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Histocompatibility antigens (hla, h-2 and other systems)
Mice
Minor Histocompatibility Antigens - genetics
Molecular immunology
Molecular Sequence Data
Peptides - genetics
Peptides - immunology
Rats
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Summary:Molecular identification proved Mta, the maternally transmitted antigen of mice, to be a model minor histocompatibility (H) antigen. It consists of a peptide, MTF, that is presented on the cell surface by an H-2 class-I molecule, HMT. MTF is derived from ND1, a mitochondrially encoded protein, and the amino-terminal N-formyl-methionine is essential for binding to HMT; conservative substitutions at the sixth residue causes MTF to be a minor H antigen. HMT is encoded by the M3 gene at the telomeric end of the H-2 complex. The peptide-binding site of HMT is hydrophobic, and allelic forms of the mature protein differ by only three amino acids. Homologues and analogues of the mouse Mta system have recently been identified in rats.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.iy.09.040191.002031