Investigation of Serrated Roll Surface Differences on Ribbon Thickness During Roller Compaction

Many parameters are considered when developing a roller compaction process. However, roll serration volume is generally not considered when using serrated rolls. It was hypothesized that serration volume of concavo-convex rolls can have a significant effect on ribbon thickness due to differences in...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2007-01, Vol.12 (6), p.603-608
Main Authors: Daugherity, Patrick D., Chu, Jennifer H.
Format: Article
Language:English
Subjects:
Biological and medical sciences
concavo-convex rolls
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders
ribbon thickness
roll serrations
roller compaction
Tablets
Technology, Pharmaceutical
TF-mini
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Summary:Many parameters are considered when developing a roller compaction process. However, roll serration volume is generally not considered when using serrated rolls. It was hypothesized that serration volume of concavo-convex rolls can have a significant effect on ribbon thickness due to differences in nip angle. Experiments were conducted to investigate ribbon thickness using different roll sets having a range of serration volumes. Roll sets with approximately twice the serration volume produce ribbons 20-25% greater in thickness. These results correlated with physical measurements taken of the serrations from each set. Thus, differences in roll serration volume can significantly affect ribbon thickness.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450701563012