Novel HCV NS5B polymerase inhibitors derived from 4-1',1'-dioxo-1',4'-dihydro1'λ6-benzo(1',1',4'] thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3. Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2008, Vol.18 (11), p.3446-3455
Main Authors: LI, Lian-Sheng, YUEFEN ZHOU, RUEBSAM, Frank, WEBBER, Stephen E, SHAH, Amit M, TSAN, Mei, SHOWALTER, Richard E, PATEL, Rupal, LEBRUN, Laurie A, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, MURPHY, Douglas E, KAMRAN, Ruhi, BROOKS, Jennifer, SERGEEVA, Maria V, KIRKOVSKY, Leo, QIANG ZHAO, KISSINGER, Charles R, STANKOVIC, Nebojsa, JINGJING ZHAO, DRAGOVICH, Peter S, BERTOLINI, Thomas, ZHONGXIANG SUN, AYIDA, Benjamin, TRAN, Chinh V
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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ISSN:0960-894X
1464-3405