A new lignan and anti-inflammatory flavonoids from Kerria japonica

A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit sig...

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Bibliographic Details
Published in:Journal of asian natural products research 2008-05, Vol.10 (5), p.435-438
Main Authors: Wu, Jian, Feng, Jia-Quan, Zhao, Wei-Min
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Biological and medical sciences
Drugs, Chinese Herbal - chemistry
flavonoids
Flavonoids - chemistry
Flavonoids - isolation & purification
General pharmacology
Kerria japonica
Kerria japonica (L.) DC
lignan
Lignans - chemistry
Lignans - isolation & purification
Male
Medical sciences
Mice
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rosaceae
Rosaceae - chemistry
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Summary:A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit significant anti-inflammatory activities in mice in vivo with an inhibitory rate of 25.5% (p 
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020801892375