A new lignan and anti-inflammatory flavonoids from Kerria japonica

A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit sig...

Full description

Saved in:
Bibliographic Details
Published in:Journal of asian natural products research 2008-05, Vol.10 (5), p.435-438
Main Authors: Wu, Jian, Feng, Jia-Quan, Zhao, Wei-Min
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Biological and medical sciences
Drugs, Chinese Herbal - chemistry
flavonoids
Flavonoids - chemistry
Flavonoids - isolation & purification
General pharmacology
Kerria japonica
Kerria japonica (L.) DC
lignan
Lignans - chemistry
Lignans - isolation & purification
Male
Medical sciences
Mice
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rosaceae
Rosaceae - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33
cites cdi_FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33
container_end_page 438
container_issue 5
container_start_page 435
container_title Journal of asian natural products research
container_volume 10
creator Wu, Jian
Feng, Jia-Quan
Zhao, Wei-Min
description A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit significant anti-inflammatory activities in mice in vivo with an inhibitory rate of 25.5% (p 
doi_str_mv 10.1080/10286020801892375
format article
fullrecord <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_20416409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69192136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33</originalsourceid><addsrcrecordid>eNqFkEFPGzEQhS1EBSHlB_SC9kJv23psx_ZKXCAqbUUkLvS8mvV6K6NdO9gbIP8eRwntIRI5jOZJ_t7T-BHyBeg3oJp-B8q0pCxL0BXjanZEJiCUKhkDfpx1fi83wCk5S-mRUgYg2Qk5BS2koJpPyM114e1L0bu_Hn2Bvs0zutL5rsdhwDHEdZHlc_DBtanoYhiKOxujw-IRl8E7g5_Jpw77ZM93e0r-3P54mP8qF_c_f8-vF6UREsZSt0Kqpp11mhsFglEruEHT6gapskbNqsY2UqBslBIIIHQLptENbLTtOJ-Sr9vcZQxPK5vGenDJ2L5Hb8Mq1bKCKv9bHgRZ7oVptUmELWhiSCnarl5GN2Bc10DrTcP1XsPZc7ELXzWDbf87dpVm4HIHYDLYdxG9cekfx6iADFaZu9pyuesQB3wJsW_rEdd9iO8m_tEd6qB9z1WPryN_Aye2p2k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21022873</pqid></control><display><type>article</type><title>A new lignan and anti-inflammatory flavonoids from Kerria japonica</title><source>Taylor and Francis Science and Technology Collection</source><creator>Wu, Jian ; Feng, Jia-Quan ; Zhao, Wei-Min</creator><creatorcontrib>Wu, Jian ; Feng, Jia-Quan ; Zhao, Wei-Min</creatorcontrib><description>A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit significant anti-inflammatory activities in mice in vivo with an inhibitory rate of 25.5% (p &lt; 0.001) and 13.1% (p &lt; 0.05), respectively.</description><identifier>ISSN: 1028-6020</identifier><identifier>EISSN: 1477-2213</identifier><identifier>DOI: 10.1080/10286020801892375</identifier><identifier>PMID: 18464083</identifier><language>eng</language><publisher>Abingdon: Taylor &amp; Francis Group</publisher><subject>Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation &amp; purification ; Biological and medical sciences ; Drugs, Chinese Herbal - chemistry ; flavonoids ; Flavonoids - chemistry ; Flavonoids - isolation &amp; purification ; General pharmacology ; Kerria japonica ; Kerria japonica (L.) DC ; lignan ; Lignans - chemistry ; Lignans - isolation &amp; purification ; Male ; Medical sciences ; Mice ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Rosaceae ; Rosaceae - chemistry</subject><ispartof>Journal of asian natural products research, 2008-05, Vol.10 (5), p.435-438</ispartof><rights>Copyright Taylor &amp; Francis Group, LLC 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33</citedby><cites>FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20416409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18464083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Feng, Jia-Quan</creatorcontrib><creatorcontrib>Zhao, Wei-Min</creatorcontrib><title>A new lignan and anti-inflammatory flavonoids from Kerria japonica</title><title>Journal of asian natural products research</title><addtitle>J Asian Nat Prod Res</addtitle><description>A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit significant anti-inflammatory activities in mice in vivo with an inhibitory rate of 25.5% (p &lt; 0.001) and 13.1% (p &lt; 0.05), respectively.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation &amp; purification</subject><subject>Biological and medical sciences</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - isolation &amp; purification</subject><subject>General pharmacology</subject><subject>Kerria japonica</subject><subject>Kerria japonica (L.) DC</subject><subject>lignan</subject><subject>Lignans - chemistry</subject><subject>Lignans - isolation &amp; purification</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Rosaceae</subject><subject>Rosaceae - chemistry</subject><issn>1028-6020</issn><issn>1477-2213</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkEFPGzEQhS1EBSHlB_SC9kJv23psx_ZKXCAqbUUkLvS8mvV6K6NdO9gbIP8eRwntIRI5jOZJ_t7T-BHyBeg3oJp-B8q0pCxL0BXjanZEJiCUKhkDfpx1fi83wCk5S-mRUgYg2Qk5BS2koJpPyM114e1L0bu_Hn2Bvs0zutL5rsdhwDHEdZHlc_DBtanoYhiKOxujw-IRl8E7g5_Jpw77ZM93e0r-3P54mP8qF_c_f8-vF6UREsZSt0Kqpp11mhsFglEruEHT6gapskbNqsY2UqBslBIIIHQLptENbLTtOJ-Sr9vcZQxPK5vGenDJ2L5Hb8Mq1bKCKv9bHgRZ7oVptUmELWhiSCnarl5GN2Bc10DrTcP1XsPZc7ELXzWDbf87dpVm4HIHYDLYdxG9cekfx6iADFaZu9pyuesQB3wJsW_rEdd9iO8m_tEd6qB9z1WPryN_Aye2p2k</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Wu, Jian</creator><creator>Feng, Jia-Quan</creator><creator>Zhao, Wei-Min</creator><general>Taylor &amp; Francis Group</general><general>Taylor &amp; Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>A new lignan and anti-inflammatory flavonoids from Kerria japonica</title><author>Wu, Jian ; Feng, Jia-Quan ; Zhao, Wei-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - isolation &amp; purification</topic><topic>Biological and medical sciences</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - isolation &amp; purification</topic><topic>General pharmacology</topic><topic>Kerria japonica</topic><topic>Kerria japonica (L.) DC</topic><topic>lignan</topic><topic>Lignans - chemistry</topic><topic>Lignans - isolation &amp; purification</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Rosaceae</topic><topic>Rosaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Feng, Jia-Quan</creatorcontrib><creatorcontrib>Zhao, Wei-Min</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of asian natural products research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jian</au><au>Feng, Jia-Quan</au><au>Zhao, Wei-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new lignan and anti-inflammatory flavonoids from Kerria japonica</atitle><jtitle>Journal of asian natural products research</jtitle><addtitle>J Asian Nat Prod Res</addtitle><date>2008-05</date><risdate>2008</risdate><volume>10</volume><issue>5</issue><spage>435</spage><epage>438</epage><pages>435-438</pages><issn>1028-6020</issn><eissn>1477-2213</eissn><abstract>A new lignan named kerinol (1) as well as 12 known compounds were isolated from the twigs of Kerria japonica (L.) DC (Rosaceae). Their structures were elucidated on the basis of spectroscopic analysis. Linariin (3) and isolinariin B (4), two major flavonoids of K. japonica, were found to exhibit significant anti-inflammatory activities in mice in vivo with an inhibitory rate of 25.5% (p &lt; 0.001) and 13.1% (p &lt; 0.05), respectively.</abstract><cop>Abingdon</cop><pub>Taylor &amp; Francis Group</pub><pmid>18464083</pmid><doi>10.1080/10286020801892375</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1028-6020
ispartof Journal of asian natural products research, 2008-05, Vol.10 (5), p.435-438
issn 1028-6020
1477-2213
language eng
recordid cdi_pascalfrancis_primary_20416409
source Taylor and Francis Science and Technology Collection
subjects Animals
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Biological and medical sciences
Drugs, Chinese Herbal - chemistry
flavonoids
Flavonoids - chemistry
Flavonoids - isolation & purification
General pharmacology
Kerria japonica
Kerria japonica (L.) DC
lignan
Lignans - chemistry
Lignans - isolation & purification
Male
Medical sciences
Mice
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rosaceae
Rosaceae - chemistry
title A new lignan and anti-inflammatory flavonoids from Kerria japonica
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T21%3A03%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20lignan%20and%20anti-inflammatory%20flavonoids%20from%20Kerria%20japonica&rft.jtitle=Journal%20of%20asian%20natural%20products%20research&rft.au=Wu,%20Jian&rft.date=2008-05&rft.volume=10&rft.issue=5&rft.spage=435&rft.epage=438&rft.pages=435-438&rft.issn=1028-6020&rft.eissn=1477-2213&rft_id=info:doi/10.1080/10286020801892375&rft_dat=%3Cproquest_pasca%3E69192136%3C/proquest_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c461t-8d467bd5f83c71420e43cacd8ba07ec759beb64a6b774a1148d1cb8b1a114ef33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=21022873&rft_id=info:pmid/18464083&rfr_iscdi=true