Effect of the first bath with chlorhexidine on skin colonization with Staphylococcus aureus in normal healthy term newborns

A masked randomized clinical trial was conducted in 93 neonates who received the first bath with chlorhexidine (experimental) (n=44) or neutral liquid soap (control) (n=49). Three samples were collected for culture from the neonates' right axilla skin before bath, 30 min and 24 h after bath. Im...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2008, Vol.40 (8), p.615-620
Main Authors: Da Cunha, Maria L., Procianoy, Renato S., Franceschini, Débora T., De Oliveira, Laura L., Cunha, Maria L.
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiseptics
Bacterial diseases
Baths
Biological and medical sciences
Chi-Square Distribution
Chlorhexidine - pharmacology
Female
Human bacterial diseases
Humans
Infant, Newborn
Infectious diseases
Male
Medical sciences
Methicillin-Resistant Staphylococcus aureus - growth & development
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Pharmacology. Drug treatments
Skin - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - growth & development
Staphylococcus aureus - isolation & purification
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Summary:A masked randomized clinical trial was conducted in 93 neonates who received the first bath with chlorhexidine (experimental) (n=44) or neutral liquid soap (control) (n=49). Three samples were collected for culture from the neonates' right axilla skin before bath, 30 min and 24 h after bath. Immediately before bath, Staphylococcus aureus colonization prevalence was 10.2% (n=5) in control and 4.5% (n=2) in the experimental group (p=0.74). 30 min after bath, S. aureus prevalence was 20.4% (n=10) in control and 2.3% (n=1) in the experimental group (p=0.017). 24 h after bath, S. aureus prevalence was 36.7% (n=18) in control and 13.6% (n=6) in the experimental group (p=0.021). There was no occurrence of sepsis in the first month in both groups. In conclusion, a first bath with chlorhexidine reduced S. aureus colonization on the newborn's skin in a 24-h period.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540801932447