Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2009, Vol.17 (3), p.1193-1206
Main Authors: NAGATA, Tsutomu, YOSHINO, Toshiharu, OSANAI, Ken, SUZUKI, Makoto, KANNO, Hideyuki, HAGINOYA, Noriyasu, YOSHIKAWA, Kenji, NAGAMOCHI, Masatoshi, KOBAYASHI, Syozo, KOMORIYA, Satoshi, YOKOMIZO, Aki, MUTO, Ryo, YAMAGUCHI, Mitsuhiro
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Medical sciences
Pharmacology. Drug treatments
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1206
container_issue 3
container_start_page 1193
container_title Bioorganic & medicinal chemistry
container_volume 17
creator NAGATA, Tsutomu
YOSHINO, Toshiharu
OSANAI, Ken
SUZUKI, Makoto
KANNO, Hideyuki
HAGINOYA, Noriyasu
YOSHIKAWA, Kenji
NAGAMOCHI, Masatoshi
KOBAYASHI, Syozo
KOMORIYA, Satoshi
YOKOMIZO, Aki
MUTO, Ryo
YAMAGUCHI, Mitsuhiro
description
format article
fullrecord <record><control><sourceid>pascalfrancis</sourceid><recordid>TN_cdi_pascalfrancis_primary_21127411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21127411</sourcerecordid><originalsourceid>FETCH-pascalfrancis_primary_211274113</originalsourceid><addsrcrecordid>eNqNj91Kw0AQhYMoWH_eYW-EFrKQTZO08U78wSsv1AuhlDLd3ZCRzU7YLKWr-NS-gJvqA3g1M-d8cM4cJRNRVAWfz2txnEyyulrybFlXp8nZMLxnWZYXtZgk33c4SNppFxg17ImvpuI5zV_S8mXGc_65mpZctoYcoVVkohTMTILbkg0GOrT0xUs-Vdhp3wYzOtDRyARpqNX7YNYR-HV5kZZplS64195BG5Qj3yJ8kKFVmRZcrvvgUKHVMecQso8RSrMDeqgxXtfshtlY2aSsJ6-tZ2AVIwfGBAbS404zhU5Lz9C2uEVPbnyuiV7c3uAiOWnADPryb54nVw_3r7ePvIdBgmkcWInDpnfYgQubXIh8UQgx_y_3A5g9e2c</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>NAGATA, Tsutomu ; YOSHINO, Toshiharu ; OSANAI, Ken ; SUZUKI, Makoto ; KANNO, Hideyuki ; HAGINOYA, Noriyasu ; YOSHIKAWA, Kenji ; NAGAMOCHI, Masatoshi ; KOBAYASHI, Syozo ; KOMORIYA, Satoshi ; YOKOMIZO, Aki ; MUTO, Ryo ; YAMAGUCHI, Mitsuhiro</creator><creatorcontrib>NAGATA, Tsutomu ; YOSHINO, Toshiharu ; OSANAI, Ken ; SUZUKI, Makoto ; KANNO, Hideyuki ; HAGINOYA, Noriyasu ; YOSHIKAWA, Kenji ; NAGAMOCHI, Masatoshi ; KOBAYASHI, Syozo ; KOMORIYA, Satoshi ; YOKOMIZO, Aki ; MUTO, Ryo ; YAMAGUCHI, Mitsuhiro</creatorcontrib><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Bioorganic &amp; medicinal chemistry, 2009, Vol.17 (3), p.1193-1206</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21127411$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGATA, Tsutomu</creatorcontrib><creatorcontrib>YOSHINO, Toshiharu</creatorcontrib><creatorcontrib>OSANAI, Ken</creatorcontrib><creatorcontrib>SUZUKI, Makoto</creatorcontrib><creatorcontrib>KANNO, Hideyuki</creatorcontrib><creatorcontrib>HAGINOYA, Noriyasu</creatorcontrib><creatorcontrib>YOSHIKAWA, Kenji</creatorcontrib><creatorcontrib>NAGAMOCHI, Masatoshi</creatorcontrib><creatorcontrib>KOBAYASHI, Syozo</creatorcontrib><creatorcontrib>KOMORIYA, Satoshi</creatorcontrib><creatorcontrib>YOKOMIZO, Aki</creatorcontrib><creatorcontrib>MUTO, Ryo</creatorcontrib><creatorcontrib>YAMAGUCHI, Mitsuhiro</creatorcontrib><title>Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa</title><title>Bioorganic &amp; medicinal chemistry</title><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNj91Kw0AQhYMoWH_eYW-EFrKQTZO08U78wSsv1AuhlDLd3ZCRzU7YLKWr-NS-gJvqA3g1M-d8cM4cJRNRVAWfz2txnEyyulrybFlXp8nZMLxnWZYXtZgk33c4SNppFxg17ImvpuI5zV_S8mXGc_65mpZctoYcoVVkohTMTILbkg0GOrT0xUs-Vdhp3wYzOtDRyARpqNX7YNYR-HV5kZZplS64195BG5Qj3yJ8kKFVmRZcrvvgUKHVMecQso8RSrMDeqgxXtfshtlY2aSsJ6-tZ2AVIwfGBAbS404zhU5Lz9C2uEVPbnyuiV7c3uAiOWnADPryb54nVw_3r7ePvIdBgmkcWInDpnfYgQubXIh8UQgx_y_3A5g9e2c</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>NAGATA, Tsutomu</creator><creator>YOSHINO, Toshiharu</creator><creator>OSANAI, Ken</creator><creator>SUZUKI, Makoto</creator><creator>KANNO, Hideyuki</creator><creator>HAGINOYA, Noriyasu</creator><creator>YOSHIKAWA, Kenji</creator><creator>NAGAMOCHI, Masatoshi</creator><creator>KOBAYASHI, Syozo</creator><creator>KOMORIYA, Satoshi</creator><creator>YOKOMIZO, Aki</creator><creator>MUTO, Ryo</creator><creator>YAMAGUCHI, Mitsuhiro</creator><general>Elsevier</general><scope>IQODW</scope></search><sort><creationdate>2009</creationdate><title>Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa</title><author>NAGATA, Tsutomu ; YOSHINO, Toshiharu ; OSANAI, Ken ; SUZUKI, Makoto ; KANNO, Hideyuki ; HAGINOYA, Noriyasu ; YOSHIKAWA, Kenji ; NAGAMOCHI, Masatoshi ; KOBAYASHI, Syozo ; KOMORIYA, Satoshi ; YOKOMIZO, Aki ; MUTO, Ryo ; YAMAGUCHI, Mitsuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pascalfrancis_primary_211274113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGATA, Tsutomu</creatorcontrib><creatorcontrib>YOSHINO, Toshiharu</creatorcontrib><creatorcontrib>OSANAI, Ken</creatorcontrib><creatorcontrib>SUZUKI, Makoto</creatorcontrib><creatorcontrib>KANNO, Hideyuki</creatorcontrib><creatorcontrib>HAGINOYA, Noriyasu</creatorcontrib><creatorcontrib>YOSHIKAWA, Kenji</creatorcontrib><creatorcontrib>NAGAMOCHI, Masatoshi</creatorcontrib><creatorcontrib>KOBAYASHI, Syozo</creatorcontrib><creatorcontrib>KOMORIYA, Satoshi</creatorcontrib><creatorcontrib>YOKOMIZO, Aki</creatorcontrib><creatorcontrib>MUTO, Ryo</creatorcontrib><creatorcontrib>YAMAGUCHI, Mitsuhiro</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Bioorganic &amp; medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGATA, Tsutomu</au><au>YOSHINO, Toshiharu</au><au>OSANAI, Ken</au><au>SUZUKI, Makoto</au><au>KANNO, Hideyuki</au><au>HAGINOYA, Noriyasu</au><au>YOSHIKAWA, Kenji</au><au>NAGAMOCHI, Masatoshi</au><au>KOBAYASHI, Syozo</au><au>KOMORIYA, Satoshi</au><au>YOKOMIZO, Aki</au><au>MUTO, Ryo</au><au>YAMAGUCHI, Mitsuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa</atitle><jtitle>Bioorganic &amp; medicinal chemistry</jtitle><date>2009</date><risdate>2009</risdate><volume>17</volume><issue>3</issue><spage>1193</spage><epage>1206</epage><pages>1193-1206</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><cop>Amsterdam</cop><pub>Elsevier</pub></addata></record>
fulltext fulltext
identifier ISSN: 0968-0896
ispartof Bioorganic & medicinal chemistry, 2009, Vol.17 (3), p.1193-1206
issn 0968-0896
1464-3391
language eng
recordid cdi_pascalfrancis_primary_21127411
source ScienceDirect Freedom Collection 2022-2024
subjects Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Medical sciences
Pharmacology. Drug treatments
title Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonylamino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride : A novel, potent and orally active direct inhibitor of factor Xa
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T22%3A17%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pascalfrancis&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20N-%5B(1R,2S,5S)-2-%7B%5B(5-chloroindol-2-yl)carbonylamino%7D-5-(dimethylcarbamoyl)cyclohexyl%5D-5-methyl-4,5,6,7-tetrahydrothiazolo%5B5,4-c%5Dpyridine-2-carboxamide%20hydrochloride%20:%20A%20novel,%20potent%20and%20orally%20active%20direct%20inhibitor%20of%20factor%20Xa&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=NAGATA,%20Tsutomu&rft.date=2009&rft.volume=17&rft.issue=3&rft.spage=1193&rft.epage=1206&rft.pages=1193-1206&rft.issn=0968-0896&rft.eissn=1464-3391&rft_id=info:doi/&rft_dat=%3Cpascalfrancis%3E21127411%3C/pascalfrancis%3E%3Cgrp_id%3Ecdi_FETCH-pascalfrancis_primary_211274113%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true