High Concentrations of Manganese in Mueller-Hinton Agar Increase MICs of Tigecycline Determined by Etest

MICs of tigecycline determined by Etest were 4 to 12 times (three ATCC strains) and 2 to 8 times (50 clinical isolates) higher in Mueller-Hinton agar from Merck than in Mueller-Hinton agar from either Oxoid or Difco. This was related to a much higher concentration of manganese in the medium from Mer...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-03, Vol.47 (3), p.827-829
Main Authors: Fernández-Mazarrasa, Carlos, Mazarrasa, Olav, Calvo, Jorge, del Arco, Asunción, Martínez-Martínez, Luis
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteriological Techniques - standards
Bacteriology
Biological and medical sciences
Culture Media - chemistry
Fundamental and applied biological sciences. Psychology
Humans
Manganese - analysis
Microbial Sensitivity Tests
Microbiology
Minocycline - analogs & derivatives
Minocycline - pharmacology
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Summary:MICs of tigecycline determined by Etest were 4 to 12 times (three ATCC strains) and 2 to 8 times (50 clinical isolates) higher in Mueller-Hinton agar from Merck than in Mueller-Hinton agar from either Oxoid or Difco. This was related to a much higher concentration of manganese in the medium from Merck.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.02464-08