mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model

Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other s...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 1997-12, Vol.63 (12), p.4945-4947
Main Authors: Marron, L, Emerson, N, Gahan, C.G.M, Hill, C
Format: Article
Language:English
Subjects:
Acids
Animals
Bacteriology
Biological and medical sciences
Biotechnology
Disease Models, Animal
food contamination
Fundamental and applied biological sciences. Psychology
Hot Temperature
human health and safety
Hydrogen-Ion Concentration
Listeria monocytogenes - genetics
Listeria monocytogenes - growth & development
Listeria monocytogenes - pathogenicity
Listeriosis - etiology
medicine
Mice
Mice, Inbred BALB C
Microbiology
Mutation
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Stress, Physiological - genetics
Virulence - genetics
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Summary:Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.
ISSN:0099-2240
1098-5336
DOI:10.1128/aem.63.12.4945-4947.1997