Levels of Serum Interleukin (IL)‐6 and Gingival Crevicular Fluid of IL‐1β and Prostaglandin E2 Among Non‐Smoking Subjects With Gingivitis and Type 2 Diabetes

Background: The goal of this study was to assess whether non‐smoking patients with type 2 diabetes present with increased levels of local and systemic proinflammatory mediators and, if so, whether such an increase is associated with enhanced clinical gingival inflammation compared to non‐smoking pat...

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Published in:Journal of periodontology (1970) 2009-02, Vol.80 (2), p.307-316
Main Authors: Andriankaja, O.M., Barros, S.P., Moss, K., Panagakos, F.S., DeVizio, W., Beck, J., Offenbacher, S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Gingivitis
interleukin‐1 beta
interleukin‐6
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
prostaglandin E2
Tobacco, tobacco smoking
Toxicology
type 2 diabetes
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Summary:Background: The goal of this study was to assess whether non‐smoking patients with type 2 diabetes present with increased levels of local and systemic proinflammatory mediators and, if so, whether such an increase is associated with enhanced clinical gingival inflammation compared to non‐smoking patients without diabetes. Methods: We used a cross‐sectional database consisting of 725 self‐reported lifelong non‐smokers aged 53 to 74 years. Gingival crevicular fluid (GCF) levels of interleukin (IL)‐1β and prostaglandin E2 (PGE2) and serum levels of IL‐6 were measured using enzyme‐linked immunosorbent assay. No participant had probing depth >3 mm. Participants with bleeding on probing (BOP) in
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2009.080385