Value of Gallium-67 Scintigraphy in Monitoring the Renal Activity in Lupus Nephritis

In this study, we evaluated the relationship between the gallium uptake in the kidneys and the results of renal biopsy. The renal uptake of gallium in 32 patients with lupus nephritis were evaluated according to the classification of the World Health Organization, the activity index (AI), and the ch...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 1998, Vol.27 (1), p.42-45
Main Authors: LIN, W.-Y, LAN, J.-L, CHENG, K.-Y, WANG, S.-J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biopsy
Disease Progression
False Positive Reactions
Female
Gallium Radioisotopes
Humans
Kidney - diagnostic imaging
Kidney - physiopathology
Lupus Nephritis - diagnostic imaging
Lupus Nephritis - physiopathology
Male
Medical sciences
Middle Aged
Radionuclide Imaging
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Tropical medicine
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Summary:In this study, we evaluated the relationship between the gallium uptake in the kidneys and the results of renal biopsy. The renal uptake of gallium in 32 patients with lupus nephritis were evaluated according to the classification of the World Health Organization, the activity index (AI), and the chronicity index (CI). AI was significantly higher in patients with a positive gallium scan when compared with patients with a negative gallium scan (p = 0.0007). However, change in gallium uptake was not related to the CI or WHO classification (p = 0.68 and p = 0.79 respectively). Of the 16 patients with AI > or = 9, 13 (81.25%) had a positive gallium scan, while only 3 (18.7%) of the patients with AI < 9 had a positive scan. In addition, all patients (100%) with AI > or = 11 showed a positive gallium scan. We conclude that renal imaging with gallium has a good correlation with AI, and may be a useful alternative to renal biopsy in patients with lupus nephritis.
ISSN:0300-9742
1502-7732
DOI:10.1080/030097498441164