Fatal Epstein-Barr Virus Primo Infection in a 25-Year-Old Man Treated with Azathioprine for Crohn's Disease

We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specif...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-04, Vol.47 (4), p.1252-1254
Main Authors: N'Guyen, Y, Andreoletti, L, Patey, M, Lecoq-Lafon, C, Cornillet, P, Léon, A, Jaussaud, R, Fieschi, C, Strady, C
Format: Article
Language:English
Subjects:
Adult
Azathioprine - adverse effects
Azathioprine - therapeutic use
Biological and medical sciences
Case Reports
Crohn Disease - complications
Crohn Disease - drug therapy
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Fatal Outcome
Fundamental and applied biological sciences. Psychology
Human health and pathology
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Infectious diseases
Life Sciences
Male
Microbiology
Miscellaneous
Virology
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Summary:We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.02052-08