Fullerene Derivatives Attenuate Bronchoconstriction Induced by Xanthine-Xanthine Oxidase

The intratracheal instillation of xanthine-xanthine oxidase caused a marked decrease in dynamic respiratory compliance, indicating airway constriction. The constriction was significantly attenuated by fullerenol-1, but not by other agents or receptor antagonists.

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Bibliographic Details
Published in:Fullerene science and technology 1997-01, Vol.5 (7), p.1337-1345
Main Authors: Lai, Yih-Loong, Chiou, Wen-Yi, Chiang, Long Y.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Derivatives
Enzymes
Medical sciences
Pharmacology. Drug treatments
Respiratory mechanics
Respiratory system
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Description
Summary:The intratracheal instillation of xanthine-xanthine oxidase caused a marked decrease in dynamic respiratory compliance, indicating airway constriction. The constriction was significantly attenuated by fullerenol-1, but not by other agents or receptor antagonists.
ISSN:1064-122X
1532-2343
DOI:10.1080/15363839708013324