ApoE ε4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Summary A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between...

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Bibliographic Details
Published in:Epilepsy research 2009-08, Vol.85 (2), p.311-313
Main Authors: Kauffman, Marcelo Andrés, Pereira-de-Silva, Nahuel, Consalvo, Damián, Kochen, Silvia
Format: Article
Language:English
Subjects:
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Summary A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between ApoE ε4 allele and postictal confusion in our population ( χ2 = 1.67; d.f. = 1; p = 0.2). Thus, the association between ApoE ε4 allele and postictal confusion still needs to be fully investigated in different and independent populations.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2009.03.012