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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline y-secretase inhibitors

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Published in:	Bioorganic & medicinal chemistry letters 2009, Vol.19 (17), p.4920-4923
Main Authors:	TRUONG, Anh P, AUBELE, Danielle L, GAROFALO, Albert W, KEIM, Pamela S, JING WU, DAPPEN, Michael S, WONG, Marina, GOLDBACH, Erich, QUINN, Kevin P, SAUER, John-Michael, BRIGHAM, Elizabeth F, WALLACE, William, PROBST, Gary D, NGUYEN, Lan, HEMPHILL, Susanna S, BOVA, Michael P, BASI, Guriqbal, NEITZEL, Martin L, SEMKO, Chris M, BOWERS, Simeon, DRESSEN, Darren, HOM, Roy K, KONRADI, Andrei W, SHAM, Hing L
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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container_issue	17
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container_title	Bioorganic & medicinal chemistry letters
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creator	TRUONG, Anh P AUBELE, Danielle L GAROFALO, Albert W KEIM, Pamela S JING WU DAPPEN, Michael S WONG, Marina GOLDBACH, Erich QUINN, Kevin P SAUER, John-Michael BRIGHAM, Elizabeth F WALLACE, William PROBST, Gary D NGUYEN, Lan HEMPHILL, Susanna S BOVA, Michael P BASI, Guriqbal NEITZEL, Martin L SEMKO, Chris M BOWERS, Simeon DRESSEN, Darren HOM, Roy K KONRADI, Andrei W SHAM, Hing L
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subjects	Biological and medical sciences Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
title	Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline y-secretase inhibitors
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