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SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro
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| Published in: | Antimicrobial Agents and Chemotherapy 2010-02, Vol.54 (2), p.660-672 |
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| container_end_page | 672 |
| container_issue | 2 |
| container_start_page | 660 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 54 |
| creator | HOPKINS, Sam SCORNEAUX, Bernard ZHUHUI HUANG MURRAY, Michael G WRING, Stephen SMITLEY, Craig HARRIS, Richard ERDMANN, Frank FISCHER, Gunter RIBEILL, Yves |
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| doi_str_mv | 10.1128/AAC.00660-09 |
| format | article |
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1752 N Street N.W. • Washington DC 20036
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</description><subject>a-Interferon</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral activity</topic><topic>Antiviral Agents</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacokinetics</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Cyclophilin A - metabolism</topic><topic>Cyclosporins</topic><topic>Cyclosporins - chemistry</topic><topic>Cyclosporins - pharmacokinetics</topic><topic>Cyclosporins - pharmacology</topic><topic>Cyclosporins - therapeutic use</topic><topic>Cytochrome P450</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Activation - drug effects</topic><topic>Enzymes</topic><topic>Haplorhini</topic><topic>Hepacivirus</topic><topic>Hepacivirus - drug effects</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis C - drug therapy</topic><topic>Hepatitis C virus</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunosuppressive Agents</topic><topic>Immunosuppressive Agents - chemistry</topic><topic>Infectious diseases</topic><topic>Interleukin 2</topic><topic>Interleukin-2 - metabolism</topic><topic>Jurkat Cells - drug effects</topic><topic>Jurkat Cells - metabolism</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Liver</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>P-Glycoprotein</topic><topic>Peptidylprolyl isomerase</topic><topic>Peripheral blood mononuclear cells</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Replication</topic><topic>Ribavirin</topic><topic>RNA</topic><topic>RNA viruses</topic><topic>RNA, Viral</topic><topic>RNA, Viral - genetics</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOPKINS, Sam</creatorcontrib><creatorcontrib>SCORNEAUX, Bernard</creatorcontrib><creatorcontrib>ZHUHUI HUANG</creatorcontrib><creatorcontrib>MURRAY, Michael G</creatorcontrib><creatorcontrib>WRING, Stephen</creatorcontrib><creatorcontrib>SMITLEY, Craig</creatorcontrib><creatorcontrib>HARRIS, Richard</creatorcontrib><creatorcontrib>ERDMANN, Frank</creatorcontrib><creatorcontrib>FISCHER, Gunter</creatorcontrib><creatorcontrib>RIBEILL, Yves</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOPKINS, Sam</au><au>SCORNEAUX, Bernard</au><au>ZHUHUI HUANG</au><au>MURRAY, Michael G</au><au>WRING, Stephen</au><au>SMITLEY, Craig</au><au>HARRIS, Richard</au><au>ERDMANN, Frank</au><au>FISCHER, Gunter</au><au>RIBEILL, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><stitle>AAC</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>54</volume><issue>2</issue><spage>660</spage><epage>672</epage><pages>660-672</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19933795</pmid><doi>10.1128/AAC.00660-09</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2010-02, Vol.54 (2), p.660-672 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_22362397 |
| source | American Society for Microbiology Journals; PubMed Central |
| subjects | a-Interferon Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral Agents Antiviral Agents - chemistry Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Cell Line Cells, Cultured Cyclophilin A - metabolism Cyclosporins Cyclosporins - chemistry Cyclosporins - pharmacokinetics Cyclosporins - pharmacology Cyclosporins - therapeutic use Cytochrome P450 Dogs Dose-Response Relationship, Drug Enzyme Activation - drug effects Enzymes Haplorhini Hepacivirus Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C - drug therapy Hepatitis C virus Hepatocytes - drug effects Hepatocytes - metabolism Human viral diseases Humans Immunosuppressive Agents Immunosuppressive Agents - chemistry Infectious diseases Interleukin 2 Interleukin-2 - metabolism Jurkat Cells - drug effects Jurkat Cells - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Liver Medical sciences Mice Molecular Structure P-Glycoprotein Peptidylprolyl isomerase Peripheral blood mononuclear cells Pharmacology. Drug treatments Rats Replication Ribavirin RNA RNA viruses RNA, Viral RNA, Viral - genetics Viral diseases Viral hepatitis Virus Replication - drug effects |
| title | SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro |
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