The Effect of the New Triazole, Voriconazole (UK-109,496), on the Interactions of Candida albicans and Candida krusei with Endothelial Cells

In this study, we investigated how voriconazole affects specific endothelial cell interactions utilizing both fluconazole-susceptible S and resistant R Candida albican s strains (C. albicans s and C. albicans R , respectively) as well as Candida krusei. Our data show that exposing C. albicansS to vo...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 1998-02, Vol.10 (1), p.7-16
Main Authors: Fratti, R.A., Belanger, P.H., Sanati, H., Ghannoum, M.A.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Candida albicans - growth & development
Cell Adhesion - drug effects
Cells, Cultured
Endothelium, Vascular - drug effects
Endothelium, Vascular - microbiology
Fluconazole - pharmacology
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pyrimidines - pharmacology
Triazoles - pharmacology
Voriconazole
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Summary:In this study, we investigated how voriconazole affects specific endothelial cell interactions utilizing both fluconazole-susceptible S and resistant R Candida albican s strains (C. albicans s and C. albicans R , respectively) as well as Candida krusei. Our data show that exposing C. albicansS to voriconazole significantly reduced its adherence to endothelial cells (p
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.1998.10.1.7