Mortality rate and outcome factors in mixed cryoglobulinaemia: the impact of hepatitis C virus

Objectives: Mixed cryoglobulinaemia (MC) is a chronic small-vessel vasculitis. Shortly after the discovery of hepatitis C virus (HCV) in 1989, an association between HCV infection and MC was being increasingly reported, suggesting the potential pathogenetic implication of HCV in most of the cases th...

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Bibliographic Details
Published in:Scandinavian Journal of Rheumatology 2010-03, Vol.39 (2), p.167-170
Main Authors: Rossa, A Della, Tavoni, A, D'Ascanio, A, Catarsi, E, Marchi, F, Bencivelli, W, Salvadori, S, Migliorini, P, Bombardieri, S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cause of Death
Cryoglobulinemia - complications
Cryoglobulinemia - mortality
Diseases of the osteoarticular system
Female
Hepacivirus
Hepatitis C - complications
Hepatitis C - mortality
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Treatment Outcome
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Summary:Objectives: Mixed cryoglobulinaemia (MC) is a chronic small-vessel vasculitis. Shortly after the discovery of hepatitis C virus (HCV) in 1989, an association between HCV infection and MC was being increasingly reported, suggesting the potential pathogenetic implication of HCV in most of the cases that had been previously diagnosed as essential MC. A number of studies have pointed out prognostic factors linked to mortality in this disorder. None of them, however, have clarified the impact of HCV discovery on the natural history of the disease. The aim of the present study was to evaluate mortality in MC after the discovery of HCV infection. Methods: We retrospectively collected clinical and serological data in 70 unselected HCV-positive patients being followed up at our unit from 1990. Clinical and prognostic factors linked to poor outcome were evaluated. Results: Chronic hepatitis, renal involvement, and intestinal vasculitis were the most frequent causes of death. Conclusion: Compared to other series, the outcome in our MC seemed to be better. Factors linked to a poor outcome were renal involvement, widespread vasculitis, male sex, and cryocrit.
ISSN:0300-9742
1502-7708
1502-7732
DOI:10.3109/03009740903313639