In Vitro Ultrasound Influence on Cutaneous Permeation of Hyaluronidase

In vitro skin permeation of hyaluronidase enzyme and the ultrasound (US) effects on cutaneous permeation of this enzyme were investigated. Diffusion cell technique, porcine skins, buffer solution, and a hydrophilic gel + hyaluronidase (100 TUR/g), were used for study. The experimental groups were: g...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2010-06, Vol.31 (6), p.756-759
Main Authors: Zague, Vivian, Chorilli, Marlus, Polacow, Maria Luíza Ozores, Pires-de-Campos, Maria Sílvia Mariani, Leonardi, Gislaine Ricci
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Hyaluronidase
in vitro cutaneous permeation
ultrasound
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Summary:In vitro skin permeation of hyaluronidase enzyme and the ultrasound (US) effects on cutaneous permeation of this enzyme were investigated. Diffusion cell technique, porcine skins, buffer solution, and a hydrophilic gel + hyaluronidase (100 TUR/g), were used for study. The experimental groups were: gel + enzyme and gel + enzyme + US. The activity of permeated hyaluronidase was determined by turbydimetric method in spectrophotometer at 400 nm. Gel + enzyme group permitted a diffusion of 26.89 ± 3.82 TUR of hyaluronidase in the total time of 240 minutes. However, the other group did not produce significant differences (p 
ISSN:0193-2691
1532-2351
DOI:10.1080/01932690903333051