Automated synthesis of 18F-labelled analogs of metomidate, vorozole and harmine using commercial platform

• Published in: Journal of labelled compounds & radiopharmaceuticals 2010-04, Vol.53 (4), p.169-171
• Main Authors: Rahman, Obaidur, Erlandsson, Maria, Blom, Elisabeth, Långström, Bengt
• Format: Article
• Language: English
• Subjects: 18F-labelling; [18F]FETO; [18F]FHAR; [18F]FVOZ; automated synthesis; Biological and medical sciences; Contrast media. Radiopharmaceuticals; Medical sciences; PET; Pharmacology. Drug treatments
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/jlcr.1742

Three 18F‐labelled PET tracers, 2‐[18F]fluoroethyl 1‐[(1R)‐1‐phenylethyl]‐1H‐imidazole‐5‐carboxylate ([18F]FETO), 6‐[(S)‐(4‐chlorophenyl)‐(1H)‐1,2,4‐triazol‐1‐yl)methyl]‐1‐(2‐[18F]fluoroethyl)‐1H‐benzotriazole ([18F]FVOZ) and 7‐[2‐(2‐[18F]fluoroethoxy)ethoxy]‐1‐9H‐β‐carboline ([18F]FHAR) were synthesized by a one‐step nucleophilic fluorination using the automated commercial platform TRACERLab FXFN. The labelled products were obtained with 16–20% isolated decay corrected radiochemical yields after 70–75 min synthesis time. The radiochemical and chemical purities were more than 98% in all cases. The synthesis using commercial platform may make these tracers more accessible for clinical research. Copyright © 2010 John Wiley & Sons, Ltd. Automated synthesis of three 18F‐labelled PET tracers, 2‐[18F]fluoroethyl 1‐[(1R)‐1‐phenylethyl]‐1H‐imidazole‐5‐carboxylate ([18F]FETO), 6‐[(S)‐(4‐chlorophenyl)‐(1H)‐1,2,4‐triazol‐1‐yl)‐methyl]‐1‐(2‐[18F]fluoroethyl)‐1H‐benzotriazole ([18F]FVOZ) and 7‐[2‐(2‐[18F]fluoroethoxy)ethoxy]‐1‐9H‐β‐carboline ([18F]FHAR) using the automated commercial platform TRACERLab FXFN has been described. Copyright © 2010 John Wiley & Sons, Ltd.