Electroanalytical Characteristics of Lercanidipine and its Voltammetric Determination in Pharmaceuticals and Human Serum on Boron-Doped Diamond Electrode

The electrooxidative behavior and determination of lercanidipine (LRC) were investigated in aqueous acetonitrile medium at a boron-doped diamond electrode using voltammetric techniques. The LRC in selected supporting electrolyte presents a well-defined anodic response at 0.944 V, studied by the prop...

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Bibliographic Details
Published in:Analytical letters 2010-08, Vol.43 (12), p.1958-1975
Main Authors: Altun, Yuksel, Uslu, Bengi, Ozkan, Sibel A.
Format: Article
Language:English
Subjects:
Acetonitrile
Analytical chemistry
Anodic
Boron-doped diamond electrode
Chemistry
Dosage form
Electrochemical methods
Electrodes
Electrolytes
Exact sciences and technology
Human
Lercanidipine
Mathematical analysis
Oxidation
Pharmaceuticals
Serums
Voltammetry
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Summary:The electrooxidative behavior and determination of lercanidipine (LRC) were investigated in aqueous acetonitrile medium at a boron-doped diamond electrode using voltammetric techniques. The LRC in selected supporting electrolyte presents a well-defined anodic response at 0.944 V, studied by the proposed method. The linear response was obtained in the ranges of 4 × 10 −6 to 2 × 10 −4  mmol L −1 range in 0.5 mmol L −1 sulfuric acid supporting electrolyte and 1 × 10 −5 to 8 × 10 −5  mmol L −1 range in spiked serum sample for square wave voltammetric technique. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage form and in the biological sample, respectively.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032711003687047