A Highly Convergent Synthesis of Tricyclic N-Heterocycles Coupling an Ugi Reaction with a Tandem SN2′-Heck Double Cyclization

A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a SN2′ cyclization followed by an intramolecular Heck reaction.

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Bibliographic Details
Published in:Journal of organic chemistry 2010-08, Vol.75 (15), p.5134-5143
Main Authors: Riva, Renata, Banfi, Luca, Basso, Andrea, Cerulli, Valentina, Guanti, Giuseppe, Pani, Marcella
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Preparations and properties
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Description
Summary:A small library of natural product-like compounds has been assembled by coupling an Ugi multicomponent reaction with two postcondensation transformations, carried out in one-pot fashion: a SN2′ cyclization followed by an intramolecular Heck reaction.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo100859y