A Detoxified Extract of Rhus verniciflua Stokes Upregulated the Expression of BDNF and GDNF in the Rat Brain and the Human Dopaminergic Cell Line SH-SY5Y

Rhus verniciflua Stokes (RVS) has traditionally been used as a food supplement and a traditional herbal medicine for centuries in Korea. This study attempted to evaluate the effects of RVS on the expression of Brain derived neurotrophic factor (BDNF) and Glial cell line-derived neurotrophic factor (...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (10), p.1997-2004
Main Authors: SAPKOTA, Kumar, KIM, Seung, KIM, Myung-Kon, KIM, Sung-Jun
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cell Line
Dopamine - metabolism
Fundamental and applied biological sciences. Psychology
gene expression
Glial Cell Line-Derived Neurotrophic Factor - genetics
Glial Cell Line-Derived Neurotrophic Factor - metabolism
Humans
Male
neuroprotection
neurotrophic factors
Parkinson's disease
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Rhus - chemistry
Rhus verniciflua
RNA, Messenger - genetics
RNA, Messenger - metabolism
Up-Regulation - drug effects
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cited_by cdi_FETCH-LOGICAL-c509t-99fe82b77c6d3a217ad503180522ab58734eaf7a94287130ecc081f41ac4bf583
cites cdi_FETCH-LOGICAL-c509t-99fe82b77c6d3a217ad503180522ab58734eaf7a94287130ecc081f41ac4bf583
container_end_page 2004
container_issue 10
container_start_page 1997
container_title Bioscience, biotechnology, and biochemistry
container_volume 74
creator SAPKOTA, Kumar
KIM, Seung
KIM, Myung-Kon
KIM, Sung-Jun
description Rhus verniciflua Stokes (RVS) has traditionally been used as a food supplement and a traditional herbal medicine for centuries in Korea. This study attempted to evaluate the effects of RVS on the expression of Brain derived neurotrophic factor (BDNF) and Glial cell line-derived neurotrophic factor (GDNF) in SH-SY5Y cells and the rat brain. The results indicated that RVS is a potent inducer of Neurotrophic factor (NTF) production both in vitro and in vivo. Treatment with 10 μg/ml and 10 mg/kg RVS for 4 h of SH-SY5Y cells and rats yielded significant increases in BDNF and GDNF protein levels. We also detected BDNF and GDNF immunoreactive neurons in the rat brain. Both BDNF and GDNF-immunohistochemical staining was markedly enhanced in the animals treated with RVS. These results suggest that RVS serves as an ideal adjuvant in regard to regulating NTF expression, and can contribute to neuroprotection in neurodegenerative diseases.
doi_str_mv 10.1271/bbb.100165
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ispartof Bioscience, biotechnology, and biochemistry, 2010, Vol.74 (10), p.1997-2004
issn 0916-8451
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source Oxford Journals Online; EZB Electronic Journals Library
subjects Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cell Line
Dopamine - metabolism
Fundamental and applied biological sciences. Psychology
gene expression
Glial Cell Line-Derived Neurotrophic Factor - genetics
Glial Cell Line-Derived Neurotrophic Factor - metabolism
Humans
Male
neuroprotection
neurotrophic factors
Parkinson's disease
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Rhus - chemistry
Rhus verniciflua
RNA, Messenger - genetics
RNA, Messenger - metabolism
Up-Regulation - drug effects
title A Detoxified Extract of Rhus verniciflua Stokes Upregulated the Expression of BDNF and GDNF in the Rat Brain and the Human Dopaminergic Cell Line SH-SY5Y
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