Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana

The present study describes the analgesic effects of the hydroalcoholic extract (HE) obtained from the aerial parts of Alternanthera brasiliana in two models of pain in mice. Such an extract, given intraperitoneally or orally produced significant and long‐lasting (0.5–4 h) antinociception when evalu...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 1998-06, Vol.12 (4), p.279-281
Main Authors: De Souza, Marcia M., Kern, P., Floriani, Ana E. O., Cechinel-Filho, V.
Format: Article
Language:English
Subjects:
Alternanthera brasiliana
analgesia
Biological and medical sciences
formalin test
General pharmacology
hydroalcoholic extract
Medical sciences
mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemical analysis
writhing test
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 281
container_issue 4
container_start_page 279
container_title Phytotherapy research
container_volume 12
creator De Souza, Marcia M.
Kern, P.
Floriani, Ana E. O.
Cechinel-Filho, V.
description The present study describes the analgesic effects of the hydroalcoholic extract (HE) obtained from the aerial parts of Alternanthera brasiliana in two models of pain in mice. Such an extract, given intraperitoneally or orally produced significant and long‐lasting (0.5–4 h) antinociception when evaluated against acetic acid‐induced abdominal constrictions. In the formalin test, the HE inhibited both the first and second phases of formalin‐induced pain. Furthermore, the HE was more potent than some standard drugs, such as aspirin, indomethacin and dipyrone, when evaluated against acetic acid‐induced abdominal constrictions. These results suggest a strong analgesic effect for HE, possibly related to the presence of sterols, terpenes and phenolic compounds, confirming the popular use of A. brasiliana against dolorous processes. © 1998 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/(SICI)1099-1573(199806)12:4<279::AID-PTR224>3.0.CO;2-G
format article
fullrecord <record><control><sourceid>wiley_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_2380431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PTR224</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3014-c56003438ec5d1c40a46ec6e57a8ad724765c2ee99a6a1c660aa82f9bde6af383</originalsourceid><addsrcrecordid>eNo90E1v00AQBuAVAolQ-A8-cGgPDrMfXnsDqhQZGiIZwkdRIy6jyXpNFlw72rXU5t_jyFVOI8288x4exq45zDmAeHf5c12urzgYk_Isl5fcmAL0FRcL9UHkZrFYrj-m325_CKGu5Rzm5ea9SFfP2Oz88pzNwGQ8VbzYvmSvYvwLAEaAmrG7ZUftHxe9TQ6hP7gweBeTvkko2R_r0FNr-33fjmf3OASyQ9LvBvKdq5Mm9PfJsh1c6Kgb9i5QsgsUfeupo9fsRUNtdG-e5gX7dfPptvycVpvVulxWqZfAVWozDSCVLJzNam4VkNLOapflVFCdC5XrzArnjCFN3GoNRIVozK52mhpZyAv2duo9ULTUNoE66yMegr-ncEQhC1CSj7HtFHvwrTuezxzwRIwnYTxx4YkLJ2HkAhWOwjgC4wSMEgHLDQpcPW3G6nSq9nFwj-dqCv9Q5zLP8O7rCr98r7aVrH4jl_8BLrWHUg</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>De Souza, Marcia M. ; Kern, P. ; Floriani, Ana E. O. ; Cechinel-Filho, V.</creator><creatorcontrib>De Souza, Marcia M. ; Kern, P. ; Floriani, Ana E. O. ; Cechinel-Filho, V.</creatorcontrib><description>The present study describes the analgesic effects of the hydroalcoholic extract (HE) obtained from the aerial parts of Alternanthera brasiliana in two models of pain in mice. Such an extract, given intraperitoneally or orally produced significant and long‐lasting (0.5–4 h) antinociception when evaluated against acetic acid‐induced abdominal constrictions. In the formalin test, the HE inhibited both the first and second phases of formalin‐induced pain. Furthermore, the HE was more potent than some standard drugs, such as aspirin, indomethacin and dipyrone, when evaluated against acetic acid‐induced abdominal constrictions. These results suggest a strong analgesic effect for HE, possibly related to the presence of sterols, terpenes and phenolic compounds, confirming the popular use of A. brasiliana against dolorous processes. © 1998 John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/(SICI)1099-1573(199806)12:4&lt;279::AID-PTR224&gt;3.0.CO;2-G</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Alternanthera brasiliana ; analgesia ; Biological and medical sciences ; formalin test ; General pharmacology ; hydroalcoholic extract ; Medical sciences ; mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phytochemical analysis ; writhing test</subject><ispartof>Phytotherapy research, 1998-06, Vol.12 (4), p.279-281</ispartof><rights>Copyright © 1998 John Wiley &amp; Sons, Ltd.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2380431$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>De Souza, Marcia M.</creatorcontrib><creatorcontrib>Kern, P.</creatorcontrib><creatorcontrib>Floriani, Ana E. O.</creatorcontrib><creatorcontrib>Cechinel-Filho, V.</creatorcontrib><title>Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The present study describes the analgesic effects of the hydroalcoholic extract (HE) obtained from the aerial parts of Alternanthera brasiliana in two models of pain in mice. Such an extract, given intraperitoneally or orally produced significant and long‐lasting (0.5–4 h) antinociception when evaluated against acetic acid‐induced abdominal constrictions. In the formalin test, the HE inhibited both the first and second phases of formalin‐induced pain. Furthermore, the HE was more potent than some standard drugs, such as aspirin, indomethacin and dipyrone, when evaluated against acetic acid‐induced abdominal constrictions. These results suggest a strong analgesic effect for HE, possibly related to the presence of sterols, terpenes and phenolic compounds, confirming the popular use of A. brasiliana against dolorous processes. © 1998 John Wiley &amp; Sons, Ltd.</description><subject>Alternanthera brasiliana</subject><subject>analgesia</subject><subject>Biological and medical sciences</subject><subject>formalin test</subject><subject>General pharmacology</subject><subject>hydroalcoholic extract</subject><subject>Medical sciences</subject><subject>mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phytochemical analysis</subject><subject>writhing test</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNo90E1v00AQBuAVAolQ-A8-cGgPDrMfXnsDqhQZGiIZwkdRIy6jyXpNFlw72rXU5t_jyFVOI8288x4exq45zDmAeHf5c12urzgYk_Isl5fcmAL0FRcL9UHkZrFYrj-m325_CKGu5Rzm5ea9SFfP2Oz88pzNwGQ8VbzYvmSvYvwLAEaAmrG7ZUftHxe9TQ6hP7gweBeTvkko2R_r0FNr-33fjmf3OASyQ9LvBvKdq5Mm9PfJsh1c6Kgb9i5QsgsUfeupo9fsRUNtdG-e5gX7dfPptvycVpvVulxWqZfAVWozDSCVLJzNam4VkNLOapflVFCdC5XrzArnjCFN3GoNRIVozK52mhpZyAv2duo9ULTUNoE66yMegr-ncEQhC1CSj7HtFHvwrTuezxzwRIwnYTxx4YkLJ2HkAhWOwjgC4wSMEgHLDQpcPW3G6nSq9nFwj-dqCv9Q5zLP8O7rCr98r7aVrH4jl_8BLrWHUg</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>De Souza, Marcia M.</creator><creator>Kern, P.</creator><creator>Floriani, Ana E. O.</creator><creator>Cechinel-Filho, V.</creator><general>John Wiley &amp; Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope></search><sort><creationdate>199806</creationdate><title>Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana</title><author>De Souza, Marcia M. ; Kern, P. ; Floriani, Ana E. O. ; Cechinel-Filho, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3014-c56003438ec5d1c40a46ec6e57a8ad724765c2ee99a6a1c660aa82f9bde6af383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alternanthera brasiliana</topic><topic>analgesia</topic><topic>Biological and medical sciences</topic><topic>formalin test</topic><topic>General pharmacology</topic><topic>hydroalcoholic extract</topic><topic>Medical sciences</topic><topic>mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phytochemical analysis</topic><topic>writhing test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Souza, Marcia M.</creatorcontrib><creatorcontrib>Kern, P.</creatorcontrib><creatorcontrib>Floriani, Ana E. O.</creatorcontrib><creatorcontrib>Cechinel-Filho, V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Souza, Marcia M.</au><au>Kern, P.</au><au>Floriani, Ana E. O.</au><au>Cechinel-Filho, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>1998-06</date><risdate>1998</risdate><volume>12</volume><issue>4</issue><spage>279</spage><epage>281</epage><pages>279-281</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The present study describes the analgesic effects of the hydroalcoholic extract (HE) obtained from the aerial parts of Alternanthera brasiliana in two models of pain in mice. Such an extract, given intraperitoneally or orally produced significant and long‐lasting (0.5–4 h) antinociception when evaluated against acetic acid‐induced abdominal constrictions. In the formalin test, the HE inhibited both the first and second phases of formalin‐induced pain. Furthermore, the HE was more potent than some standard drugs, such as aspirin, indomethacin and dipyrone, when evaluated against acetic acid‐induced abdominal constrictions. These results suggest a strong analgesic effect for HE, possibly related to the presence of sterols, terpenes and phenolic compounds, confirming the popular use of A. brasiliana against dolorous processes. © 1998 John Wiley &amp; Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><doi>10.1002/(SICI)1099-1573(199806)12:4&lt;279::AID-PTR224&gt;3.0.CO;2-G</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0951-418X
ispartof Phytotherapy research, 1998-06, Vol.12 (4), p.279-281
issn 0951-418X
1099-1573
language eng
recordid cdi_pascalfrancis_primary_2380431
source Wiley-Blackwell Read & Publish Collection
subjects Alternanthera brasiliana
analgesia
Biological and medical sciences
formalin test
General pharmacology
hydroalcoholic extract
Medical sciences
mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
phytochemical analysis
writhing test
title Analgesic properties of a hydroalcoholic extract obtained from Alternanthera brasiliana
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T04%3A42%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analgesic%20properties%20of%20a%20hydroalcoholic%20extract%20obtained%20from%20Alternanthera%20brasiliana&rft.jtitle=Phytotherapy%20research&rft.au=De%20Souza,%20Marcia%20M.&rft.date=1998-06&rft.volume=12&rft.issue=4&rft.spage=279&rft.epage=281&rft.pages=279-281&rft.issn=0951-418X&rft.eissn=1099-1573&rft_id=info:doi/10.1002/(SICI)1099-1573(199806)12:4%3C279::AID-PTR224%3E3.0.CO;2-G&rft_dat=%3Cwiley_pasca%3EPTR224%3C/wiley_pasca%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-i3014-c56003438ec5d1c40a46ec6e57a8ad724765c2ee99a6a1c660aa82f9bde6af383%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true