Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus

1  Section of Vascular Medicine, Divisions of 2  Internal Medicine, 3  Cardiology, 4  Endocrinology and 6  Geriatrics, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 5  Division of Pulmonary Medicine, University of Oregon Health Sciences Center, Po...

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Published in:Journal of applied physiology (1985) 1998-07, Vol.85 (1), p.310-317
Main Authors: Regensteiner, Judith G, Bauer, Timothy A, Reusch, Jane E. B, Brandenburg, Suzanne L, Sippel, Jeffrey M, Vogelsong, Andria M, Smith, Susan, Wolfel, Eugene E, Eckel, Robert H, Hiatt, William R
Format: Article
Language:English
Subjects:
Adult
Autonomic Nervous System - physiology
Biological and medical sciences
Body Composition - physiology
Densitometry
Diabetes
Diabetes Mellitus - metabolism
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Echocardiography, Doppler
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Exercise Test
Female
Heart Rate - physiology
Humans
Kinetics
Lactic Acid - blood
Medical sciences
Middle Aged
Obesity
Oxygen
Oxygen Consumption - physiology
Women
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Summary:1  Section of Vascular Medicine, Divisions of 2  Internal Medicine, 3  Cardiology, 4  Endocrinology and 6  Geriatrics, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262; and 5  Division of Pulmonary Medicine, University of Oregon Health Sciences Center, Portland, Oregon 97201 Persons with type II diabetes mellitus (DM), even without cardiovascular complications have a decreased maximal oxygen consumption ( O 2 max ) and submaximal oxygen consumption ( O 2 ) during graded exercise compared with healthy controls. We evaluated the hypothesis that change in the rate of O 2 in response to the onset of constant-load exercise (measured by O 2 -uptake kinetics) was slowed in persons with type II DM. Ten premenopausal women with uncomplicated type II DM, 10 overweight, nondiabetic women, and 10 lean, nondiabetic women had a O 2 max test. On two separate occasions, subjects performed 7-min bouts of constant-load bicycle exercise at workloads below and above the lactate threshold to enable measurements of O 2 kinetics and heart rate kinetics (measuring rate of heart rate rise). O 2 max was reduced in subjects with type II DM compared with both lean and overweight controls ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1998.85.1.310