Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-ylmethyl acetamide (BMS-066)

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2011, Vol.21 (23), p.7006-7012
Main Authors: WATTERSON, Scott H, LANGEVINE, Charles M, GREGOR, Kurt, PATTOLI, Mark A, XIAOXIA YANG, MCINTYRE, Kim W, GUCHEN YANG, GALELLA, Michael A, BOOTH-LUTE, Hollie, LAISHUN CHEN, ZHENG YANG, WANG-IVERSON, David, KIRK, Katy Van, MCKINNON, Murray, DODD, John H, BARRISH, Joel C, BURKE, James R, PITTS, William J, KEMPSON, James, JUNQUING GUO, SPERGEL, Steven H, DAS, Jagabandhu, MOQUIN, Robert V, DYCKMAN, Alaric J, NIRSCHL, David
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Digestive system
Medical sciences
Pharmacology. Drug treatments
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ISSN:0960-894X
1464-3405