Effect of Physical Properties and Emulsification Conditions on the Microsphere Size Prepared Using a Solvent Extraction Process

Microspheres were prepared using a hydrocarbon-perfluorocarbon solvent extraction process. The effect of the physical properties and the emulsification conditions on the mean microsphere size was investigated. The viscosity of the dispersed and the continuous phase greatly affected the microsphere s...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2012-02, Vol.33 (2), p.234-244
Main Authors: Heiskanen, Harri, Denifl, Peter, Hurme, Markku, Pitkänen, Päivi, Oksman, Marita
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Dispersion
Dispersions
Droplets
Emulsification
Emulsions
Emulsions. Microemulsions. Foams
Exact sciences and technology
General and physical chemistry
microsphere
Microspheres
particle size distribution
Physical properties
Solvent extraction
Viscosity
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Summary:Microspheres were prepared using a hydrocarbon-perfluorocarbon solvent extraction process. The effect of the physical properties and the emulsification conditions on the mean microsphere size was investigated. The viscosity of the dispersed and the continuous phase greatly affected the microsphere size. Smaller microspheres were produced at the same mixing intensity when the viscosity of the dispersed phase decreased. Increased continuous phase viscosity reduced the coalescenceof the droplets and hence smaller microspheres were produced. The mean microsphere size first decreased as the volume ratio of the dispersed phase to the continuous phase increased but upon further increase the mean microsphere size increased. The effect of the volume ratio on the microsphere size was linked to the surfactant concentration. The stability of the studied hydrocarbon-in-fluorocarbon emulsion is poor. One reason for the poor stability is the high density difference between the phases. The emulsion droplets were solidified by siphoning part of the emulsion in the fresh continuous phase, which extracted the solvent from the dispersed phase. The effect of emulsion transfer time between the emulsification and solidification steps on the particle size was studied but no significant effect was observedduring the controlled time interval.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2011.561166