Designing Medical Devices Based on Silicon Polymeric Material with Controlled Release of Local Anesthetics

The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen...

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Bibliographic Details
Published in:Journal of macromolecular science. Part A, Pure and applied chemistry Pure and applied chemistry, 2012-05, Vol.49 (5), p.439-444
Main Authors: Petrisor, G., Ion, R. M., Brachais, C. H., Couvercelle, J-P., Chambin, O.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
controlled release
cross-linking
drug delivery system
Exact sciences and technology
General pharmacology
Inorganic and organomineral polymers
lidocaine hydrochloride
Medical sciences
patch
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
PVA
PVP
Silicone
water-soluble polymer
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Summary:The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen from the range of local anesthetics. When the drug is restricted to the surface, it is released more rapidly than when it is allowed to spread evenly throughout the silicon structure. When hydrophilic polymers such as PVA and HEC are mixed in with the lidocaine hydrochloride and deposited on the surface of the polymer matrix, we observed that the burst effect was eliminated without modifying the overall quantity of lidocaine hydrochloride released.
ISSN:1060-1325
1520-5738
DOI:10.1080/10601325.2012.672055